227 results found
    1. Cancer Biology

    The CD73 immune checkpoint promotes tumor cell metabolic fitness

    David Allard, Isabelle Cousineau ... John Stagg
    Targeting CD73 not only enhances anti-tumor immunity but also disrupts tumor cell metabolism and hinders poly ADP ribose polymerase (PARP) activity, thus unveiling novel opportunities for combination cancer treatments.
    1. Cancer Biology
    2. Computational and Systems Biology

    Aspirin’s effect on kinetic parameters of cells contributes to its role in reducing incidence of advanced colorectal adenomas, shown by a multiscale computational study

    Yifan Wang, C Richard Boland ... Natalia L Komarova
    A mathematical model of colorectal cancer initiation shows that a change in cells’ kinetic parameters due to aspirin can account for an observed reduction in advanced adenoma age- incidence in patients treated with aspirin.
    1. Cancer Biology
    2. Immunology and Inflammation

    Optimal cancer evasion in a dynamic immune microenvironment generates diverse post-escape tumor antigenicity profiles

    Jason T George, Herbert Levine
    Theoretical modeling reveals how stochastic optimal cancer immune evasion via antigen downregulation gives rise to diverse post-escape cancer antigenic profiles in a manner dependent on the immune microenvironment.
    1. Cancer Biology
    2. Cell Biology

    TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

    Debjani Pal, Anja Pertot ... Raffaella Sordella
    Phenotypic diversity and cell state transition (i.e., acquisition of a CD44+/CD24- cell state or exposure to TGF-beta) can spur intra-tumor genetic heterogeneity and contribute to acquired resistance.
    1. Evolutionary Biology

    Group phenotypic composition in cancer

    Jean-Pascal Capp, James DeGregori ... Frédéric Thomas
    Tumoral group phenotypic compositions and their relationships with the fitness of individual malignant cells in different ecological contexts represent crucial, previously unexplored dynamics in tumor progression.
    1. Evolutionary Biology

    Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia

    Jiguang Wang, Hossein Khiabanian ... Raul Rabadan
    A general framework captures the evolutionary routes leading to the formation and progression of tumors.
    1. Cancer Biology
    2. Genetics and Genomics

    Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway

    Annie Wai Yeeng Chai, Pei San Yee ... Sok Ching Cheong
    Genome-wide CRISPR/Cas9 screens enable the identification of actionable vulnerabilities of oral squamous cell carcinoma, and their unique dependencies on YAP1 and WWTR1 of the Hippo pathway.
    1. Evolutionary Biology

    Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation

    Grant Kinsler, Kerry Geiler-Samerotte, Dmitri A Petrov
    A set of adaptive mutations affect only a small number of phenotypes that matter in the evolution condition, and yet contain substantial latent functional diversity revealed in distant environments.
    1. Cancer Biology
    2. Cell Biology

    Genetic Diversity: Driving cancer evolution

    Devon M Fitzgerald, Susan M Rosenberg
    Tumor-growth-factor-beta signaling helps cancer cells to evolve and become resistant to drugs by down-regulating accurate DNA repair.
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    1. Cell Biology
    2. Chromosomes and Gene Expression

    Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast

    Noah Dephoure, Sunyoung Hwang ... Eduardo M Torres
    Aneuploidy produces a protein expression signature characteristic of altered metabolism and redox homeostasis, and the loss of UBP6 ameliorates several aneuploidy-associated phenotypes.

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