Targeting CD73 not only enhances anti-tumor immunity but also disrupts tumor cell metabolism and hinders poly ADP ribose polymerase (PARP) activity, thus unveiling novel opportunities for combination cancer treatments.
Yifan Wang, C Richard Boland ... Natalia L Komarova
A mathematical model of colorectal cancer initiation shows that a change in cells’ kinetic parameters due to aspirin can account for an observed reduction in advanced adenoma age- incidence in patients treated with aspirin.
Theoretical modeling reveals how stochastic optimal cancer immune evasion via antigen downregulation gives rise to diverse post-escape cancer antigenic profiles in a manner dependent on the immune microenvironment.
Phenotypic diversity and cell state transition (i.e., acquisition of a CD44+/CD24- cell state or exposure to TGF-beta) can spur intra-tumor genetic heterogeneity and contribute to acquired resistance.
Jean-Pascal Capp, James DeGregori ... Frédéric Thomas
Tumoral group phenotypic compositions and their relationships with the fitness of individual malignant cells in different ecological contexts represent crucial, previously unexplored dynamics in tumor progression.
Annie Wai Yeeng Chai, Pei San Yee ... Sok Ching Cheong
Genome-wide CRISPR/Cas9 screens enable the identification of actionable vulnerabilities of oral squamous cell carcinoma, and their unique dependencies on YAP1 and WWTR1 of the Hippo pathway.
Grant Kinsler, Kerry Geiler-Samerotte, Dmitri A Petrov
A set of adaptive mutations affect only a small number of phenotypes that matter in the evolution condition, and yet contain substantial latent functional diversity revealed in distant environments.
Noah Dephoure, Sunyoung Hwang ... Eduardo M Torres
Aneuploidy produces a protein expression signature characteristic of altered metabolism and redox homeostasis, and the loss of UBP6 ameliorates several aneuploidy-associated phenotypes.