641 results found
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy

    Stefan Heinrichs, Lillian F Conover ... A Thomas Look
    Reduced expression of MYBL2 contributes to malignancies of the blood by permitting uncontrolled expansion of blood cell progenitors, implying a tumor suppressor function for this gene.
    1. Chromosomes and Gene Expression

    Tumor suppressor SMARCB1 suppresses super-enhancers to govern hESC lineage determination

    Lee F Langer, James M Ward, Trevor K Archer
    The chromatin remodeler and tumor suppressor SMARCB1 acts to restrict superenhancer function to direct neural differentiation of embryonic stem cells while repressing bivalent gene activity in the pluripotent state.
    1. Cancer Biology

    Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

    László Bányai, Maria Trexler ... László Patthy
    In contrast with earlier conclusions, negative selection has a major role in cancer evolution.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regeneration

    Robert G Hesse, Gayle K Kouklis ... Jason H Pomerantz
    Evolution of tumor suppressor genes can involve a trade-off because the acquisition of certain anti-cancer characteristics diminishes the ability to regenerate damaged tissue.
    1. Cancer Biology
    2. Evolutionary Biology

    Pervasive duplication of tumor suppressors in Afrotherians during the evolution of large bodies and reduced cancer risk

    Juan M Vazquez, Vincent J Lynch
    Duplication of tumor suppressor genes contributed to the evolution of large, long-lived elephants.
    1. Chromosomes and Gene Expression

    H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers

    Dong Fang, Haiyun Gan ... Zhiguo Zhang
    Redistribution of the PRC2 complex in H3.3K27M mutant cells to poised enhancers contributes to the global reduction of H3K27me3 in cells expressing the mutant proteins.
    1. Cell Biology
    2. Evolutionary Biology

    TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

    Michael Sulak, Lindsey Fong ... Vincent J Lynch
    Elephants escaped enhanced cancer susceptibility by evolving more master tumor suppressor genes.
    1. Cancer Biology
    2. Evolutionary Biology

    Parallel evolution of reduced cancer risk and tumor suppressor duplications in Xenarthra

    Juan Manuel Vazquez, Maria T Pena ... Vincent J Lynch
    Sloths, armadillos, and anteaters evolved genetic and cellular traits that make them remarkably cancer resistant.
    1. Medicine

    Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts

    Richard C Lauer, Marc Barry ... Wadih Arap
    PRUNE2/PCA3 axis dysregulation is an early, rather than late, event in prostate cancer tumorigenesis.
    1. Cancer Biology

    Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness

    Haritha Mathsyaraja, Jonathen Catchpole ... Robert N Eisenman
    The MYC transcription factor network member MGA is a subunit of a non-canonical Polycomb complex, which, when inactivated, accelerates tumorigenesis in mouse models of cancer and proliferation in colon organoids.

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