1,181 results found
    1. Structural Biology and Molecular Biophysics

    Structure of a type IV pilus machinery in the open and closed state

    Vicki AM Gold, Ralf Salzer ... Werner Kühlbrandt
    Electron cryo-tomography reveals a huge conformational change in the secretin domain of the type IV pilus machinery that occurs when the channel opens for pilus extrusion.
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    1. Microbiology and Infectious Disease

    Differential interaction forces govern bacterial sorting in early biofilms

    Enno R Oldewurtel, Nadzeya Kouzel ... Berenike Maier
    Differential physical interactions between bacteria in mixed microcolonies trigger cell sorting.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the bifunctional secretin complex of Thermus thermophilus

    Edoardo D'Imprima, Ralf Salzer ... Beate Averhoff
    The pilus extrusion/DNA uptake system of Thermus thermophilus contains a 13-mer of the 757-residue PilQ protein and a tightly bound protein outside the outer membrane with a role in DNA binding.
    1. Microbiology and Infectious Disease

    Thermosynechococcus switches the direction of phototaxis by a c-di-GMP-dependent process with high spatial resolution

    Daisuke Nakane, Gen Enomoto ... Takayuki Nishizaka
    Colour-controlled c-di-GMP signalling mediates directional switch of phototaxis via within-a-pole regulation of type IV pili in rod-shaped cyanobacteria Thermosynechococcus vulcanus.
    1. Microbiology and Infectious Disease

    Type VI secretion system killing by commensal Neisseria is influenced by expression of type four pili

    Rafael Custodio, Rhian M Ford ... Rachel M Exley
    The upper airway commensal, Neisseria cinerea, competes with related species using a T6SS, with antagonism modulated by the spatial dynamics of attacker and prey strains growing in a mixed community.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Substrate stiffness impacts early biofilm formation by modulating Pseudomonas aeruginosa twitching motility

    Sofia Gomez, Lionel Bureau ... Sigolene Lecuyer
    The spatial organization of pathogenic bacteria into microcolonies can be shaped by the stiffness of the substrate that they colonize, via modifications of the bacterial motility.
    1. Microbiology and Infectious Disease

    A Tad-like apparatus is required for contact-dependent prey killing in predatory social bacteria

    Sofiene Seef, Julien Herrou ... Tâm Mignot
    First identification of the molecular determinants driving contact-dependent predation in Myxococcus..
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

    Caitlin N Spaulding, Henry Louis Schreiber IV ... Edward H Egelman
    The helical rod structure and dynamic spring-like properties of the type 1 pilus are evolutionarily fine-tuned for functioning in host-pathogen interactions during urinary tract infection and gut colonization.
    1. Neuroscience

    Somatostatin-positive interneurons in the dentate gyrus of mice provide local- and long-range septal synaptic inhibition

    Mei Yuan, Thomas Meyer ... Marlene Bartos
    Somatostatin-expressing interneurons of the rodent dentate gyrus fall into at least two functionally distinct interneuron types with different synaptic integrations into the local dentate gyrus and the more distant medial septum neuronal network.
    1. Cell Biology
    2. Neuroscience

    Microtubules originate asymmetrically at the somatic golgi and are guided via Kinesin2 to maintain polarity within neurons

    Amrita Mukherjee, Paul S Brooks ... Paul T Conduit
    The somatic Golgi acts as an asymmetric MTOC within Drosophila neurons, and this, together with the action Kinesin-2, helps maintain minus-end-out microtubule polarity with proximal dendrites.

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