482 results found
    1. Developmental Biology
    2. Neuroscience

    USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin

    Chien-Hsiang Wang, Yi-Chun Huang ... Cheng-Ting Chien
    Maintenance of ubiquitin homeostasis is essential for proper control of the size of postsynaptic density and the growth of specialized membrane structure.
    1. Stem Cells and Regenerative Medicine

    The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis

    Jie Gao, Shannon M Buckley ... Iannis Aifantis
    DDB1, a component of the ubiquitin proteasome system, plays a role in both hematopoietic and embryonic stem cell self-renewal and differentiation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4

    Ombretta Foresti, Annamaria Ruggiano ... Pedro Carvalho
    Parallel branches of the ERAD pathway regulate sterol synthesis at multiple steps via feedback inhibition.
    1. Cell Biology

    Ubiquitin turnover and endocytic trafficking in yeast are regulated by Ser57 phosphorylation of ubiquitin

    Sora Lee, Jessica M Tumolo ... Jason A MacGurn
    Ser57 phosphorylation regulates ubiquitin homeostasis by inhibiting deubiquitylase-mediated recycling and promoting vacuolar degradation.
    1. Cell Biology

    Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP

    Li Zhang, Prashant Rajbhandari ... Peter Tontonoz
    The E3 ubiquitin ligase RNF145 is shown to contribute to crosstalk between the LXR and SREBP-2 pathways in the regulation of cholesterol homeostasis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins

    Min-Kyung Sung, Tanya R Porras-Yakushi ... Raymond J Deshaies
    Tom1 is the ubiquitin ligase in yeast that anchors a protein quality control pathway that rapidly eliminates ribosomal proteins that fail to assemble into ribosomes.
    1. Cell Biology
    2. Immunology and Inflammation

    Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

    Emma J Fenech, Federica Lari ... John C Christianson
    Interaction mapping of ubiquitin ligase complexes embedded in the endoplasmic reticulum membrane has identified interactors of RNF26 that influence innate immune signalling.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genetic analysis reveals functions of atypical polyubiquitin chains

    Fernando Meza Gutierrez, Deniz Simsek ... David P Toczyski
    A comprehensive genetic interaction screen uncovered biological roles of K11 linkages in amino acid homeostasis and cell cycle regulation in yeast.
    1. Cell Biology
    2. Developmental Biology

    A Non-stop identity complex (NIC) supervises enterocyte identity and protects from premature aging

    Neta Erez, Lena Israitel ... Amir Orian
    A nuclear Non-stop identity complex (NIC) supervises enterocyte (EC) identity, preserves tissue homeostasis, and prevents premature aging by maintaining EC-specific gene expression, silencing non-relevant programs, and safeguarding large-scale nuclear organization.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cdc48 regulates a deubiquitylase cascade critical for mitochondrial fusion

    Tânia Simões, Ramona Schuster ... Mafalda Escobar-Henriques
    A signaling pathway—comprising a linear sequence of the ubiquitin-selective chaperone Cdc48/p97 and the deubiquitylases Ubp12 and Ubp2—synergistically regulates mitochondrial fusion, thereby fine-tuning ubiquitylation of the mitofusin Fzo1.

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