Single-neuron synaptic imaging in vivo demonstrates that highly conserved molecules such as UNC-13, UNC-18, and protein kinase C, which are found at essentially every synapse make different functional contributions in Caenorhabditis elegans glutamatergic neurons.

Stationary dense-core vesicles depend on the CAPS-1 protein to fuse with the presynaptic membrane.

C. elegans exhibits two distinct behavioural macro-states, active and quiet wakefulness, and protein kinase A regulates switching between these two states.

A previously undetected dynamic cell structure orients the mitotic spindle of germ stem cells and grows over one daughter cell, thus helping to balance niche retention with niche exit.

A genetic approach in Caenorhabditis elegans shows that the cleaved and cytosolic form of the ubiquitin-like protein LGG-1/GABARAP is sufficient for both autophagy and embryonic development.

The sleep cycle of nematode worms adjusts to compensate for sleep disturbances, with neuropeptide Y involved in the response to minor disruptions, and the transcription factor DAF-16/FOXO in the response to major disruptions.

mRNA decapping function in neuronal cells regulates neurosecretion and intertissue signaling, affecting developmental and ageing processes in two model organisms.

Endocytosis is regulated by a protein family that recycles the AP2 clathrin adaptor by restoring the inactive form of complex.

Neurotransmission pathways from primary to secondary neurons encode odor and underlie age-related sensory behavioral declines.

A powerful sequencing approach is used to elucidate the genetic basis of a complex organismal trait, and members of the irld gene family that affect starvation resistance are identified.