Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.
The mammalian utricle can better regenerate hair cells compared to the cochlea because it maintains hair cell gene loci in a more transcriptionally accessible state.
TNFAIP2 was found to interact with IQGAP1 and Integrin β4, which activates RAC1 through TNFAIP2 and IQGAP1 and confers DNA damage-related drug resistance in triple-negative breast cancer.
A meta-analysis yields a spatiotemporal map of gene expression that provides a blueprint for nematode cuticle construction and reveals novel families of cuticular intrinsically disordered proteins.
An analysis of more than 70,000 journal articles, including 5405 that were first released as a preprint on bioRxiv, shows that articles with a preprint received 49% more attention and 36% more citations than articles without one.
The upregulation of TLN1 contributes to the metastasis of triple-negative breast cancer (TNBC), and a small-molecule C67399 was screened for blocking TLN1 and integrin β1 may hold promise for the treatment of TNBC.
Zane A Gibbs, Luis C Reza ... Angelique W Whitehurst
Anomalous expression of the testis protein ZNF165 in cancer cells promotes assembly of a neomorphic transcriptional complex that modulates transcription of TGFβ target genes to support tumor cell survival.
Elena Vasileva, Mikako Warren ... James F Amatruda
A zebrafish genetic model of Ewing sarcoma, a pediatric bone cancer, showed how molecules in the normal tissue can support tumor cells, and identified a therapeutic compound that slows tumor growth.
