249 results found
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Seasonal Influenza: The challenges of vaccine strain selection

    Amanda C Perofsky, Martha I Nelson
    New measures of influenza virus fitness could improve vaccine strain selection through more accurate forecasts of the evolution of the virus.
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    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution

    John Huddleston, John R Barnes ... Trevor Bedford
    The combination of phenotypic measures of antigenic drift and genotypic measures of functional constraint improves the accuracy of long-term seasonal influenza A/H3N2 forecasts.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Predicting evolution from the shape of genealogical trees

    Richard A Neher, Colin A Russell, Boris I Shraiman
    A general method for inferring fitness from a sample of nucleotide sequences can predict the progenitor of next year's seasonal influenza.
    1. Microbiology and Infectious Disease

    Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease

    Christopher Petro, Pablo A González ... William R Jacobs Jr
    An attenuated Herpes simplex type 2 virus deleted in glycoprotein D can be used as an effective vaccine to provide robust transferable humoral immunity and complete protection in murine intravaginal and skin infection models.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Adaptive Evolution: Can we read the future from a tree?

    Michael Lässig, Marta Łuksza
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    1. Epidemiology and Global Health

    Genetic epidemiology of dengue viruses in phase III trials of the CYD tetravalent dengue vaccine and implications for efficacy

    Maia A Rabaa, Yves Girerd-Chambaz ... Cameron P Simmons
    In large vaccine trials conducted in dengue-endemic Asia and Latin America, the CYD-TDV tetravalent dengue vaccine shows limited variation in intra-serotype efficacy in the target population for vaccination (>9 years).
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research

    Franziska Mohring, Melissa Natalie Hart ... Robert William Moon
    Optimised genome editing in P. knowlesi enables transgenic expression of a lead P. vivax vaccine candidate, revealing roles in host cell tropisms and providing tools for scalable vaccine efficacy testing.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics

    Natasha D Durham, Aditi Agrawal ... Leslie Goo
    Identification of viral and host determinants of broadly neutralizing antibodies targeting a new epitope on dengue virus that can be used to guide vaccine design.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern

    David W Hawman, Kimberly Meade-White ... Jesse H Erasmus
    A replicating RNA vaccine platform generated significant immunity against SARS-CoV2 in mice and hamsters, and can be updated to target variants of concern.
    1. Immunology and Inflammation
    2. Medicine

    Differences in the immune response elicited by two immunization schedules with an inactivated SARS-CoV-2 vaccine in a randomized phase 3 clinical trial

    Nicolás MS Gálvez, Gaspar A Pacheco ... Alexis M Kalergis
    The humoral and cellular immune responses were evaluated for two immunization schedules for the inactivated SARS-CoV-2 vaccine, CoronaVac, with two doses separated by 2 or 4 weeks, showing that these responses are mostly similar, with differences in neutralization capacities.

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