209 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels

    Anna L Miles, Stephen P Burr ... James A Nathan
    An unbiased genome-wide human forward genetic screen identifies the vacuolar ATPase complex and assembly factors as regulators of HIF stability through their actions on intracellular iron metabolism.
    1. Neuroscience

    Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity

    Zohreh Farsi, Sindhuja Gowrisankaran ... Ira Milosevic
    Parallel measurements of pH gradient and membrane potential at the single vesicle level have revealed that the synaptic vesicle acidification is initiated by removal of its clathrin coat, which blocks vesicular ATPase activity.
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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

    Gerta Hoxhaj, Edward Caddye ... Carol MacKintosh
    The ZNRF2 enzyme helps the mTOR protein complex to sense amino acid levels and regulate mammalian cell growth.
    1. Cell Biology

    The yeast H+-ATPase Pma1 promotes Rag/Gtr-dependent TORC1 activation in response to H+-coupled nutrient uptake

    Elie Saliba, Minoas Evangelinos ... Bruno André
    The H+ influx coupled to nutrient uptake and the plasma membrane H+-ATPase are central actors of the activation of target of rapamycin complex 1 (TORC1) in budding yeast Saccharomyces cerevisiae..
    1. Genetics and Genomics

    miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging

    Isabelle Schiffer, Birgit Gerisch ... Adam Antebi
    Coordinate control of lysosomal v-ATPase subunits and biogenesis factor TFEB by miR-1 identifies a key regulatory axis with strong links to age-related proteotoxic disease.
    1. Plant Biology

    The Arabidopsis V-ATPase is localized to the TGN/EE via a seed plant-specific motif

    Upendo Lupanga, Rachel Röhrich ... Karin Schumacher
    Analysis of the Arabidopsis V-ATPase reveals convergent evolution of differential targeting as well as redundancy of the endosomal and vacuolar isoforms during vegetative development.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Dynamics of mTORC1 activation in response to amino acids

    Maria Manifava, Matthew Smith ... Nicholas T Ktistakis
    Activation by amino acids causes mTORC1 to translocate transiently to the lysosomal surface.
    1. Microbiology and Infectious Disease

    Cell detoxification of secondary metabolites by P4-ATPase-mediated vesicle transport

    Yujie Li, Hui Ren ... Yan Pei
    P4-ATPase BbCrpa detoxifies secondary metabolites via a unique vesicle-mediated transport pathway that targets the compounds into vacuoles.
    1. Neuroscience

    Optical detection of three modes of endocytosis at hippocampal synapses

    Natali L Chanaday, Ege T Kavalali
    Single synaptic vesicle imaging shows that kinetically distinct endocytic pathways are differentially regulated by calcium and temperature, and influence the fidelity of synaptic vesicle protein retrieval.

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