55 results found
    1. Microbiology and Infectious Disease

    Population structuring of multi-copy, antigen-encoding genes in Plasmodium falciparum

    Yael Artzy-Randrup, Mary M Rorick ... Mercedes Pascual
    Mathematical modeling shows that local populations of the malaria parasite self-organize into a limited number of transient but distinct strains through competition for hosts in immunity space.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes

    Baira Godneeva, Maria Ninova ... Alexei Aravin
    Bonus, the Drosophila TIF1 factor, functions as a repressor of tissue-specific genes in the germline, emphasizing an important function of SUMOylation in transcriptional regulation.
    1. Microbiology and Infectious Disease

    The antigenic switching network of Plasmodium falciparum and its implications for the immuno-epidemiology of malaria

    Robert Noble, Zóe Christodoulou ... Mario Recker
    The first comprehensive analysis of antigenic switching in the malaria-causing parasite Plasmodium falciparum provides new insights into the process that prevents individuals from acquiring immunity to the disease.
    1. Computational and Systems Biology
    2. Medicine

    Local generation and efficient evaluation of numerous drug combinations in a single sample

    Vlad Elgart, Joseph Loscalzo
    Engineered local heterogeneity in drug concentration is used as a tool to encode drug treatment regimens and to predict the macroscopic cellular response to drug perturbations.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Common virulence gene expression in adult first-time infected malaria patients and severe cases

    J Stephan Wichers, Gerry Tonkin-Hill ... Anna Bachmann
    Parasites with pathogenic variant surface antigens are common in adult malaria patients with a naive immune status.
    1. Genetics and Genomics

    A large gene family in fission yeast encodes spore killers that subvert Mendel’s law

    Wen Hu, Zhao-Di Jiang ... Li-Lin Du
    Two members of a large fission yeast (Schizosaccharomyces pombe) gene family are shown to act as spore killers that enhance their own transmission into progenies by impeding the maturation of spores not inheriting them.
    1. Microbiology and Infectious Disease

    A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture

    Clare Andradi-Brown, Jan Stephan Wichers-Misterek ... Anna Bachmann
    An enhanced bioinformatic pipeline to quantify Plasmodium falciparum core gene and polymorphic var gene expression revealed changes occurring during early culture adaptation of parasites from naturally infected individuals.
    1. Evolutionary Biology

    Species-specific chromatin landscape determines how transposable elements shape genome evolution

    Yuheng Huang, Harsh Shukla, Yuh Chwen G Lee
    The ultimate driver for the substantial between-species difference in the success of transposable elements, the widely distributed genetic parasite, may lie in the overall chromatin environment.

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