Yael Artzy-Randrup, Mary M Rorick ... Mercedes Pascual
Mathematical modeling shows that local populations of the malaria parasite self-organize into a limited number of transient but distinct strains through competition for hosts in immunity space.
Bonus, the Drosophila TIF1 factor, functions as a repressor of tissue-specific genes in the germline, emphasizing an important function of SUMOylation in transcriptional regulation.
The first comprehensive analysis of antigenic switching in the malaria-causing parasite Plasmodium falciparum provides new insights into the process that prevents individuals from acquiring immunity to the disease.
Engineered local heterogeneity in drug concentration is used as a tool to encode drug treatment regimens and to predict the macroscopic cellular response to drug perturbations.
Two members of a large fission yeast (Schizosaccharomyces pombe) gene family are shown to act as spore killers that enhance their own transmission into progenies by impeding the maturation of spores not inheriting them.
Clare Andradi-Brown, Jan Stephan Wichers-Misterek ... Anna Bachmann
An enhanced bioinformatic pipeline to quantify Plasmodium falciparum core gene and polymorphic var gene expression revealed changes occurring during early culture adaptation of parasites from naturally infected individuals.
The ultimate driver for the substantial between-species difference in the success of transposable elements, the widely distributed genetic parasite, may lie in the overall chromatin environment.