849 results found
    1. Developmental Biology
    2. Neuroscience

    Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures

    Yanshu Wang, Mark F Sabbagh ... Jeremy Nathans
    Elevating beta-catenin signaling converts endothelial cells in typically fenestrated central nervous system vasculature to a blood-brain barrier (BBB) phenotype and promotes a BBB gene expression program and chromatin landscape.
    1. Stem Cells and Regenerative Medicine

    Skin vasculature and hair follicle cross-talking associated with stem cell activation and tissue homeostasis

    Kefei Nina Li, Prachi Jain ... Tudorita Tumbar
    Hair follicle epithelium and skin vasculature remodeling are coordinated during quiescence, and their cross-talking is associated with the timing of stem cell activation.
    1. Developmental Biology

    Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature

    Alexis M Ceasrine, Eugene E Lin ... Rejji Kuruvilla
    β2-adrenergic receptors control glucose metabolism by regulating cross-talk between pancreatic islet endocrine cells and vasculature during development.
    1. Neuroscience

    Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

    Saskia Bollmann, Hendrik Mattern ... Jonathan R Polimeni
    Partial-volume effects were found to be the current limit to imaging pial arteries with MRI, not their slow blood flow, and therefore advanced acquisition techniques achieving resolutions below 200 µm in vivo provide a more complete picture of these vessels.
    1. Cell Biology
    2. Developmental Biology

    tRNA synthetase counteracts c-Myc to develop functional vasculature

    Yi Shi, Xiaoling Xu ... Xiang-Lei Yang
    In addition to its cytoplasmic role for translation, the seryl-tRNA synthetase also antagonizes the c-Myc transcription factor in the nucleus to transcriptionally repress the growth factor VEGFA and ensure proper development of the vasculature in vertebrates.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration

    Michael RM Harrison, Xidi Feng ... Ching-Ling Lien
    Zebrafish develop cardiac lymphatic vessels along coronary arteries and this vasculature supports scar reduction following severe damage to the myocardium.
    1. Cell Biology
    2. Medicine

    Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension

    LouJin Song, Xian Chen ... Rachel J Roth Flach
    Lymphangiogenic therapy VEGFCc156s improved angiotensin-II-induced impairments in heart function via novel mechanisms, which include transcriptional responses to alleviate inflammation and cardiac fibrosis, and systemic responses to ameliorate hypertension.
    1. Developmental Biology
    2. Immunology and Inflammation

    Single-cell transcriptomics reveals functionally specialized vascular endothelium in brain

    Hyun-Woo Jeong, Rodrigo Diéguez-Hurtado ... Ralf H Adams
    Reactive endothelial venules are a new vessel subtype characterized by consistent expression of cell adhesion molecules, preferential leukocyte transmigration, association with perivascular macrophages, and the initiation of CNS immune responses.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Generation of vascularized brain organoids to study neurovascular interactions

    Xin-Yao Sun, Xiang-Chun Ju ... Zhen-Ge Luo
    A vessel and brain fusion organoid model provides a platform for the study of interactions between neuronal and non-neuronal components during brain development and functioning.
    1. Developmental Biology
    2. Evolutionary Biology

    The evolutionary origin of bilaterian smooth and striated myocytes

    Thibaut Brunet, Antje HL Fischer ... Detlev Arendt
    Molecular profiling of annelid myocytes reveals that the last common protostome-deuterostome ancestor already possessed a dual musculature, with visceral smooth muscles ensuring digestion and somatic striated muscles ensuring locomotion.

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