705 results found
    1. Cancer Biology

    Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

    Caroline Contat, Pierre-Benoit Ancey ... Etienne Meylan
    In lung adenocarcinoma, deleting one glucose transporter, whether it is Glut1 or Glut3 is insufficient, whereas their dual deletion reduces tumor growth.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    The dual role of chloride in synaptic vesicle glutamate transport

    Roger Chang, Jacob Eriksen, Robert H Edwards
    Whole endosome recording shows that chloride interacts with vesicular glutamate transporters as both allosteric activator and permeant ion, and although the mode of permeation differs, chloride and glutamate use a related conduction pathway.
    1. Cell Biology
    2. Neuroscience

    A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency

    Xiao Min Zhang, Urielle François ... Etienne Herzog
    In mammals, the vesicular glutamate transporter 1 acquired a proline-rich sequence that negatively regulates the spontaneous release of glutamate by reducing the exchange of synaptic vesicles along the axon.
    1. Biochemistry and Chemical Biology

    Determinants of sugar-induced influx in the mammalian fructose transporter GLUT5

    Sarah E McComas, Tom Reichenbach ... David Drew
    Computational approach shows that the occluded state in GLUT transporters is equivalent to the transition state of soluble enzymes and this has the highest affinity for the substrate sugar.
    1. Neuroscience

    Value-based attentional capture affects multi-alternative decision making

    Sebastian Gluth, Mikhail S Spektor, Jörg Rieskamp
    Speeded value-based decisions between two options can be affected by a third, high-value distractor that captures attention and slows down the choice process.
    1. Cell Biology

    Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake

    Muheeb Beg, Nazish Abdullah ... Timothy E McGraw
    Distinct phosphorylations of Akt determine the regulation of glucose uptake into fat and epithelial cells, revealing unexpected specialization in both Akt activation and its downstream control of glucose metabolism.
    1. Neuroscience

    Leave-One-Trial-Out, LOTO, a general approach to link single-trial parameters of cognitive models to neural data

    Sebastian Gluth, Nachshon Meiran
    Leave-One-Trial-Out (LOTO) is a general, efficient and easily implementable approach for inferring trial-by-trial measures of computational model parameters in order to link these measures to neural mechanisms.
    1. Neuroscience

    Paradoxical network excitation by glutamate release from VGluT3+ GABAergic interneurons

    Kenneth A Pelkey, Daniela Calvigioni ... Chris J McBain
    Glutamate cotransmission from a subset of cortical GABAergic interneurons can promote network hyperexcitability.
    1. Cell Biology
    2. Neuroscience

    Presynaptic morphology and vesicular composition determine vesicle dynamics in mouse central synapses

    Laurent Guillaud, Dimitar Dimitrov, Tomoyuki Takahashi
    In central synapses, the mobility and supply of synaptic vesicles are determined by two independent biological factors: the morphological and structural organization of nerve terminals and the molecular signature of vesicles.
    1. Neuroscience

    An essential role of acetylcholine-glutamate synergy at habenular synapses in nicotine dependence

    Silke Frahm, Beatriz Antolin-Fontes ... Ines Ibañez-Tallon
    Local elimination of acetylcholine synthesis in habenular neurons demonstrates a key role for vesicular synergy and neurotransmitter co-release in nicotine dependence.

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