86 results found
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Host-selected mutations converging on a global regulator drive an adaptive leap towards symbiosis in bacteria

    M Sabrina Pankey, Randi L Foxall ... Cheryl A Whistler
    Selective forces imposed by the squid animal host drive rapid adaptation of non-native Vibrio fischeri bacteria through convergent mutations of large effect, unmasking preexisting coordinated regulation of symbiosis.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A model symbiosis reveals a role for sheathed-flagellum rotation in the release of immunogenic lipopolysaccharide

    Caitlin A Brennan, Jason R Hunt ... Edward G Ruby
    Both beneficial and pathogenic bacteria can use their sheathed flagella during host colonization as a novel toxin-/signal-delivery mechanism.
    1. Microbiology and Infectious Disease

    Two enhancer binding proteins activate σ54-dependent transcription of a quorum regulatory RNA in a bacterial symbiont

    Ericka D Surrett, Kirsten R Guckes ... Tim I Miyashiro
    Genetic analysis and host colonization assays reveal a regulatory mechanism that enables a bacterial symbiont to bypass the constraints of quorum sensing to activate specific cellular traits necessary to colonize its host.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Abundant toxin-related genes in the genomes of beneficial symbionts from deep-sea hydrothermal vent mussels

    Lizbeth Sayavedra, Manuel Kleiner ... Jillian M Petersen
    Beneficial symbiotic bacteria encode an exceptional number of toxin-related genes that are all expressed by the symbionts in the host, supporting their key role in host-microbe interactions.
    1. Chromosomes and Gene Expression

    A simple mechanism for integration of quorum sensing and cAMP signalling in Vibrio cholerae

    Lucas M Walker, James RJ Haycocks ... David C Grainger
    Overlapping DNA-binding specificity allows global transcription factors to cooperatively bind the same DNA sites and integrate two signals in the control of gene expression.
    1. Microbiology and Infectious Disease

    The flagellar motor of Vibrio alginolyticus undergoes major structural remodeling during rotational switching

    Brittany L Carroll, Tatsuro Nishikino ... Jun Liu
    In situ structures of the flagellar motors genetically docked in CCW and CW rotational states reveal major rearrangement that facilitates rotational switch in Vibrio alginolyticus..
    1. Microbiology and Infectious Disease

    Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress

    Suneeta Chimalapati, Marcela de Souza Santos ... Kim Orth
    Considering the course of a pathogen's evolution, there appears to be interplay between secretion systems, providing unique, synergistic mechanisms to support a successful lifestyle for possibly pathogenesis, symbiosis and/or parasitosis.
    1. Evolutionary Biology

    The landscape of coadaptation in Vibrio parahaemolyticus

    Yujun Cui, Chao Yang ... Daniel Falush
    The first overview of fitness interactions within a species provides information how genetic interactions and ecology combine together to determine trait evolution.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Regional sequencing collaboration reveals persistence of the T12 Vibrio cholerae O1 lineage in West Africa

    Eme Ekeng, Serges Tchatchouang ... Shirlee Wohl
    The T12 Vibrio cholerae lineage has been continuously circulating in West Africa since at least 2012, highlighting the importance of regional disease control efforts.

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