Non-specific sodium entry inhibits T cell receptor induced gene expression and differentiation of T cells by depleting intracellular ATP and disrupting mTORC2 dependent signalling axis.
Edward JD Greenwood, Nicholas J Matheson ... Paul J Lehner
A comprehensive whole cell proteomic map describing expression time courses of >6,500 viral and cellular proteins during HIV infection identifies Vif-dependent antagonism of key cellular phosphatase PP2A.
Sander AL Palit, Daniel Vis ... Michiel S van der Heijden
A mechanistic link between TLE3 loss and glucocorticoid receptor-mediated androgen receptor inhibitor resistance supports the rationale to target GR during anti-hormonal treatment in castrate-resistant prostate cancer.
Sara Marelli, James C Williamson ... Nicholas J Matheson
Systematic screen of HIV-1 Vif mutants identifies synthetic and naturally occurring amino acid polymorphisms separating PPP2R5 and APOBEC3 family protein depletion and uncovers the mechanism of Vif-dependent cell cycle arrest.
Comprehensive mutational characterisation of VIM-2 metallo-beta-lactamase deciphered the residues responsible for key functional behavior, including translocation, stability, substrate recognition and catalysis.
Noah J Harris, Meredith L Jenkins ... John E Burke
Regulation of phosphoinositide 3 kinase (PI3Kγ) is essential in immune function, and stimuli that modulate the dynamics of the PI3Kγ helical domain can activate or inhibit kinase activity.