2,077 results found
    1. Structural Biology and Molecular Biophysics

    Viral genome structures are optimal for capsid assembly

    Jason D Perlmutter, Cong Qiao, Michael F Hagan
    Computer simulations reveal that viral nucleic acids have an ideal structure for being packaged into outer protein shells called capsids.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells

    Thorsten G Müller, Vojtech Zila ... Hans-Georg Kräusslich
    HIV-1 capsids enter the host cell nucleus, where they are partially disrupted to release the viral genome upon completion of reverse transcription.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A Vibrio cholerae viral satellite maximizes its spread and inhibits phage by remodeling hijacked phage coat proteins into small capsids

    Caroline M Boyd, Sundharraman Subramanian ... Kimberley D Seed
    A phage parasite encodes an external scaffolding protein to pirate and rearrange phage-encoded coat proteins to more efficiently transfer the phage parasite genome to new hosts and limit phage production.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Globally defining the effects of mutations in a picornavirus capsid

    Florian Mattenberger, Victor Latorre ... Ron Geller
    Comprehensive analyses of how mutations in a picornavirus capsid affect viral fitness provide novel insights into viral biology, evolution, and host interactions.
    1. Microbiology and Infectious Disease

    Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid

    Ke Peng, Walter Muranyi ... Hans-Georg Kräusslich
    A robust method to quantitatively visualize HIV-1 replication complexes in infected cells shows that these complexes remain associated with the viral capsid beyond nuclear import in primary macrophages.
    1. Physics of Living Systems

    Shape selection and mis-assembly in viral capsid formation by elastic frustration

    Carlos I Mendoza, David Reguera
    Nucleation, elasticity theory, and simulations were combined to construct a general phase diagram that elucidates the conditions for successful viral assembly and the key factors to prevent it.
    1. Structural Biology and Molecular Biophysics

    Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability

    Cihan Makbul, Michael Nassal, Bettina Böttcher
    Duck Hepatitis B core protein forms capsids with a slowly folding extension domain which folding competence is important for viral replication.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids

    Yen-Li Li, Viswanathan Chandrasekaran ... Wesley I Sundquist
    To protect mammals against retroviral infections, TRIM5 restriction factors recognize viral capsids by forming complementary hexagonal nets that can adapt to the patterns of capsid protein subunits on the viral capsid surface.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The interferon-inducible GTPase MxB promotes capsid disassembly and genome release of herpesviruses

    Manutea C Serrero, Virginie Girault ... Beate Sodeik
    Novel cell-free biochemical experiments show that the host GTPase MxB can restrict the infection of alphaherpesviruses by disassembling the sturdy viral capsids so that they can no longer protect the viral genomes.
    1. Structural Biology and Molecular Biophysics

    Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis

    Chantal L Márquez, Derrick Lau ... Till Böcking
    Disassembly of the HIV-1 capsid is a catastrophic process, whereby initiation and propagation can be controlled independently by molecules that bind to different features of the capsid lattice.

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