450 results found
    1. Microbiology and Infectious Disease

    Initiation of HIV-1 Gag lattice assembly is required for recognition of the viral genome packaging signal

    Xiao Lei, Daniel Gonçalves-Carneiro ... Paul D Bieniasz
    Initiation of the assembly of HIV-1 particles in infected cells is required to form a subviral structure that recognizes the viral RNA genome for packaging.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A pentameric protein ring with novel architecture is required for herpesviral packaging

    Allison L Didychuk, Stephanie N Gates ... Britt A Glaunsinger
    The first structures of Kaposi’s sarcoma-associated herpesvirus ORF68 and Epstein–Barr virus BFLF1, conserved and essential proteins required in herpesviruses, reveal new insights into viral genome packaging.
    1. Structural Biology and Molecular Biophysics

    Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies

    Lars-Anders Carlson, Yun Bai ... James H Hurley
    In vitro reconstitution shows how HIV-1 Gag assemblies on membranes can package the RNA genome in the presence of a vast excess of competing cellular RNAs, and that selectivity and immature lattice assembly are deeply intertwined with one another.
    1. Structural Biology and Molecular Biophysics

    Viral genome structures are optimal for capsid assembly

    Jason D Perlmutter, Cong Qiao, Michael F Hagan
    Computer simulations reveal that viral nucleic acids have an ideal structure for being packaged into outer protein shells called capsids.
    1. Microbiology and Infectious Disease

    Research: A comprehensive and quantitative exploration of thousands of viral genomes

    Gita Mahmoudabadi, Rob Phillips
    A compendium of critical genomic numbers for viruses through the lenses of different viral classification systems.
    1. Microbiology and Infectious Disease

    Parvovirus minute virus of mice interacts with sites of cellular DNA damage to establish and amplify its lytic infection

    Kinjal Majumder, Juexin Wang ... David J Pintel
    Development of a generally adaptable conformational capture assay for use in-trans identifies the specific direct interaction sites between the parvovirus minute virus of mice and the cellular genome during infection as sites of cellular DNA damage.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Viruses: Packing up the genome

    Bálint Kiss, Miklós Kellermayer
    Nucleotide and force-dependent mechanisms control how the viral genome of lambda bacteriophage is inserted into capsids.
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    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    The giant mimivirus 1.2 Mb genome is elegantly organized into a 30-nm diameter helical protein shield

    Alejandro Villalta, Alain Schmitt ... Chantal Abergel
    As a Russian doll, mimivirus dsDNA genome is folded in a nucleocapsid-like structure enclosed in the nucleoid compartment, encased in the icosahedral capsid itself decorated by long glycosylated fibrils surprisingly made of the same protein as the genomic fiber.
    1. Microbiology and Infectious Disease

    Cryo-electron tomography reveals novel features of a viral RNA replication compartment

    Kenneth J Ertel, Desirée Benefield ... Paul Ahlquist
    Cryo-electron tomography unveils striking new structural components of positive-strand virus RNA replication compartments, greatly advancing mechanistic insights into the structure, assembly, function and control of these critical complexes.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Pressure-driven release of viral genome into a host nucleus is a mechanism leading to herpes infection

    Alberto Brandariz-Nuñez, Ting Liu ... Alex Evilevitch
    Internal DNA pressure of tens of atmospheres inside a herpesvirus capsid powers ejection of the viral genome into a cell nucleus, causing infection.

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