2,453 results found
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin

    Juhye M Lee, Rachel Eguia ... Jesse D Bloom
    Single viral mutations can escape polyclonal human immunity to influenza hemagglutinin, but different mutations escape the immunity of different people.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Globally defining the effects of mutations in a picornavirus capsid

    Florian Mattenberger, Victor Latorre ... Ron Geller
    Comprehensive analyses of how mutations in a picornavirus capsid affect viral fitness provide novel insights into viral biology, evolution, and host interactions.
    1. Evolutionary Biology

    Zooanthroponotic transmission of SARS-CoV-2 and host-specific viral mutations revealed by genome-wide phylogenetic analysis

    Sana Naderi, Peter E Chen ... B Jesse Shapiro
    Several different mutations in the SARS-CoV-2 genome have occurred more times than expected by chance in either mink or deer infections, suggesting species-specific viral adaptations to these animals.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types

    Zharko Daniloski, Tristan X Jordan ... Neville E Sanjana
    A pervasive mutation in the Spike protein of the coronavirus that causes COVID-19 results in virions that are up to eightfold more infectious.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Comprehensive mapping of adaptation of the avian influenza polymerase protein PB2 to humans

    YQ Shirleen Soh, Louise H Moncla ... Jesse D Bloom
    Complete mapping of human-adaptive mutations to the avian influenza PB2 protein shows how selection at key molecular interfaces combines with evolutionary accessibility to shape viral host adaptation.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Design of an optimal combination therapy with broadly neutralizing antibodies to suppress HIV-1

    Colin LaMont, Jakub Otwinowski ... Armita Nourmohammad
    Computational evolutionary model to predict the efficacy of broadly neutralizing antibodies (bNAbs) in suppressing HIV and to design optimal combination therapy with bNAbs.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin

    Bargavi Thyagarajan, Jesse D Bloom
    Deep mutational scanning was used to comprehensively quantify the effects of mutations to influenza hemagglutinin and shows that the virus possesses a high inherent mutational tolerance at key antigenic sites.
    1. Microbiology and Infectious Disease

    Favipiravir elicits antiviral mutagenesis during virus replication in vivo

    Armando Arias, Lucy Thorne, Ian Goodfellow
    Favipiravir, a novel nucleoside analogue, can clear a persistent norovirus infection in vivo through lethal mutagenesis.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants

    Katina D Hulme, Anjana C Karawita ... Kirsty R Short
    Patients with paucigranulocytic asthma may be more susceptible to severe influenza and could potentially be source of new, more virulent, influenza virus variants.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Epistasis and entrenchment of drug resistance in HIV-1 subtype B

    Avik Biswas, Allan Haldane ... Ronald M Levy
    Drug resistance in HIV is the result of mutations, which affect fitness depending on epistatic interactions with the entire sequence background that varies within and between patient populations.

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