7,062 results found
    1. Cancer Biology

    Reproducibility in Cancer Biology: Challenges for assessing replicability in preclinical cancer biology

    Timothy M Errington, Alexandria Denis ... Brian A Nosek
    A project to repeat experiments from high-impact papers in cancer biology encountered a series of challenges, many of which were caused by a lack of detail in the original papers.
    1. Cancer Biology
    2. Computational and Systems Biology

    Investigating the replicability of preclinical cancer biology

    Timothy M Errington, Maya Mathur ... Brian A Nosek
    A project to repeat experiments from high-impact papers in cancer biology found that the effects observed in replications were frequently weaker than, or inconsistent with, the effects reported in the original papers.
    1. Cancer Biology

    Registered report: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

    Israr Khan, John Kerwin ... Reproducibility Project: Cancer Biology
    1. Cancer Biology

    Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

    John Kerwin, Israr Khan, Reproducibility Project: Cancer Biology
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but it also contains results that are not consistent with other parts of the original paper.
    1. Cancer Biology

    Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

    Anthony Essex, Javier Pineda ... Reproducibility Project: Cancer Biology
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
    1. Cancer Biology

    Science Forum: An open investigation of the reproducibility of cancer biology research

    Timothy M Errington, Elizabeth Iorns ... Brian A Nosek
    The Reproducibility Project: Cancer Biology will generate a high-quality dataset to explore questions about the reproducibility of research, and will make all data, analysis and other research materials openly available to the research community.
    1. Cell Biology
    2. Computational and Systems Biology

    Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells

    Anil Korkut, Weiqing Wang ... Chris Sander
    Data-driven systems biology models of signaling predict cellular response to untested perturbations and can nominate drug combinations to overcome drug resistance in cancer cells.
    1. Cell Biology
    2. Ecology

    Quantitative 3D-imaging for cell biology and ecology of environmental microbial eukaryotes

    Sebastien Colin, Luis Pedro Coelho ... Colomban de Vargas
    Three-dimensional fluorescence imaging of microbial eukaryotes in environmental samples allows accurate automated taxonomic profiling and quantitative data about ultrastructures and interactions of organisms.
    1. Cancer Biology

    Registered report: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma

    John Repass, Nimet Maherali ... Reproducibility Project: Cancer Biology
    1. Cancer Biology

    Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota

    Kathryn Eaton, Ali Pirani ... Reproducibility Project: Cancer Biology
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but it also contains results that are not consistent with other parts of the original paper.

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