686 results found
    1. Microbiology and Infectious Disease

    Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse

    Jingtao Lilue, Urs Benedikt Müller ... Jonathan C Howard
    Mechanisms that enable wild mice to survive infection with strains of the Toxoplasma gondii parasite virulent enough to kill laboratory mice offer an explanation for how these parasites have been able to persist in the mouse population.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda

    François Blanquart, Mary Kate Grabowski ... Christophe Fraser
    Analysis of epidemiological data reveals that viral loads in newly HIV-1 infected individuals in Uganda have declined for two decades, and evolutionary modelling shows that attenuation of the virus explains this decline.
    1. Plant Biology

    Multiple pairs of allelic MLA immune receptor-powdery mildew AVRA effectors argue for a direct recognition mechanism

    Isabel ML Saur, Saskia Bauer ... Paul Schulze-Lefert
    Allelic MLA immune receptors have an exceptional propensity to directly detect sequence-unrelated pathogen effectors and this feature might have facilitated functional diversification of the receptor in the host population.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence

    Tingting Wang, Wenju Sun ... Jian Yan
    The transcription factor (TF)-binding specificities of Pseudomonas aeruginosa allow us to predict virulence-associated TFs and their target genes, which will facilitate to find effective treatment and prevention for its associated diseases.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Parallel evolution of Pseudomonas aeruginosa phage resistance and virulence loss in response to phage treatment in vivo and in vitro

    Meaghan Castledine, Daniel Padfield ... Angus Buckling
    Parallel evolutionary dynamics were found in vivo and in vitro, showing that laboratory studies can be predictive of certain phenotypic outcomes of clinical phage therapy (phage-mediated decolonization).
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants

    Katina D Hulme, Anjana C Karawita ... Kirsty R Short
    Patients with paucigranulocytic asthma may be more susceptible to severe influenza and could potentially be source of new, more virulent, influenza virus variants.
    1. Ecology

    Harbouring public good mutants within a pathogen population can increase both fitness and virulence

    Richard J Lindsay, Michael J Kershaw ... Ivana Gudelj
    Cooperation theory and a novel synthetic infection system provides a mechanistic understanding of why a seemingly successful disease management strategy can have devastating consequences for infected hosts.
    1. Microbiology and Infectious Disease

    NAD kinase promotes Staphylococcus aureus pathogenesis by supporting production of virulence factors and protective enzymes

    Clarisse Leseigneur, Laurent Boucontet ... Olivier Dussurget
    Staphylococcus aureus NAD kinase promotes infection by protecting bacteria from host antimicrobial defenses and by supporting production of major virulence factors.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    A long-term epigenetic memory switch controls bacterial virulence bimodality

    Irine Ronin, Naama Katsowich ... Nathalie Q Balaban
    Hysteretic switching between virulence states has been observed in a human pathogen.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Selection on plastic adherence leads to hyper-multicellular strains and incidental virulence in the budding yeast

    Luke I Ekdahl, Juliana A Salcedo ... Helen A Murphy
    Yeast that were evolved to adhere to plastic surfaces for a few hundred generations became hyper-adherent and more virulent.

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