752 results found
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Within-host evolutionary dynamics of seasonal and pandemic human influenza A viruses in young children

    Alvin X Han, Zandra C Felix Garza ... Colin A Russell
    The longer duration of seasonal influenza virus infection in young children may provide opportunities for within-host evolution as a result of maintenance of genetic diversity through mutation-selection balance.
    1. Microbiology and Infectious Disease

    LINE-1 retrotransposons facilitate horizontal gene transfer into poxviruses

    M Julhasur Rahman, Sherry L Haller ... Stefan Rothenburg
    A new experimental system of horizontal gene transfer demonstrates that host retrotransposons facilitate the transfer of host genes into poxviruses.
    1. Microbiology and Infectious Disease

    Respiratory syncytial virus co-opts host mitochondrial function to favour infectious virus production

    MengJie Hu, Keith E Schulze ... David A Jans
    RSV's unique ability to co-opt host cell mitochondria to facilitate viral infection reveals the RSV-mitochondrial interface as a viable target for therapeutic intervention.
    1. Evolutionary Biology

    Adaptive evolution of nontransitive fitness in yeast

    Sean W Buskirk, Alecia B Rokes, Gregory I Lang
    A series of selective events, each improving fitness relative to an immediate predecessor, can result in organisms that are less fit compared to a distant ancestor.
    1. Evolutionary Biology

    Host-pathogen coevolution increases genetic variation in susceptibility to infection

    Elizabeth ML Duxbury, Jonathan P Day ... Ben Longdon
    A history of coevolution increases genetic variation in the susceptibility of Drosophila to viruses, largely by introducing major-effect resistance polymorphisms into populations.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control

    István Bartha, Jonathan M Carlson ... Jacques Fellay
    An innovative strategy in genome analysis has generated a detailed description of how pathogens mutate when facing human genetic diversity.
    1. Ecology
    2. Microbiology and Infectious Disease

    Ecology and evolution of viruses infecting uncultivated SUP05 bacteria as revealed by single-cell- and meta-genomics

    Simon Roux, Alyse K Hawley ... Matthew B Sullivan
    Single-cell amplified genome sequencing uncovers virus-host interactions in uncultivated sulfur-oxidizing bacteria with relevance to coupled biogeochemical cycling in marine oxygen minimum zones.
    1. Microbiology and Infectious Disease

    Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats

    Melinda Ng, Esther Ndungo ... Kartik Chandran
    NPC1 is a genetic determinant of filovirus susceptibility in bats, and some variations in bat NPC1 may reflect host adaptations to reduce filovirus replication and virulence.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The contrasting phylodynamics of human influenza B viruses

    Dhanasekaran Vijaykrishna, Edward C Holmes ... Ian G Barr
    The analysis of the genomes of two lineages of influenza B virus (Victoria and Yamagata) reveal that their phylodynamics are fundamentally different, and are determined by a complex relationship between virus transmission, age of infection and receptor binding preference.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Recurrent evolution of high virulence in isolated populations of a DNA virus

    Tom Hill, Robert L Unckless
    The same host–virus interactions can evolve multiple times in nature, due to the high effective mutation rate of viruses, and provide interesting systems of study.

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