Alvin X Han, Zandra C Felix Garza ... Colin A Russell
The longer duration of seasonal influenza virus infection in young children may provide opportunities for within-host evolution as a result of maintenance of genetic diversity through mutation-selection balance.
RSV's unique ability to co-opt host cell mitochondria to facilitate viral infection reveals the RSV-mitochondrial interface as a viable target for therapeutic intervention.
A series of selective events, each improving fitness relative to an immediate predecessor, can result in organisms that are less fit compared to a distant ancestor.
Elizabeth ML Duxbury, Jonathan P Day ... Ben Longdon
A history of coevolution increases genetic variation in the susceptibility of Drosophila to viruses, largely by introducing major-effect resistance polymorphisms into populations.
NPC1 is a genetic determinant of filovirus susceptibility in bats, and some variations in bat NPC1 may reflect host adaptations to reduce filovirus replication and virulence.
Dhanasekaran Vijaykrishna, Edward C Holmes ... Ian G Barr
The analysis of the genomes of two lineages of influenza B virus (Victoria and Yamagata) reveal that their phylodynamics are fundamentally different, and are determined by a complex relationship between virus transmission, age of infection and receptor binding preference.
The same host–virus interactions can evolve multiple times in nature, due to the high effective mutation rate of viruses, and provide interesting systems of study.