Christopher M Ciarleglio, Arseny S Khakhalin ... Carlos D Aizenman
The diversity of electrophysiological phenotypes of neurons in a functional network increases over development, but can be modulated, and even reduced by sensory experience; allowing them to adapt to a changing and growing brain.
The development of complex motion processing in higher-level visual cortex involves functional changes in primary visual cortex, indicating coordinated development in multiple nodes of the visual hierarchy.
Mehmet Neset Özel, Marion Langen ... P Robin Hiesinger
Long-term live imaging in intact developing Drosophila brains reveals a role for N-Cadherin-mediated fast filopodial dynamics and growth cone stabilization during neural circuit assembly.
Robin J Vigouroux, Quénol Cesar ... Kim Tuyen Nguyen-Ba-Charvet
A new eye-specific Dcc mutant combined with an improved clearing protocol for the eye and brain (EyeDISCO) reveals the requirement of the receptor Dcc for retinal development and maintenance.
Isabella Farhy-Tselnicker, Matthew M Boisvert ... Nicola J Allen
RNA sequencing and genetic mouse models reveal that transcriptional changes to astrocytes in the developing cortex are not intrinsic but influenced by their environment and determine that expression of astrocyte synapse-regulating genes and neuronal synaptogenesis is modulated by ongoing astrocyte-neuron communication.
Children with ASD showed a significant divergence in gaze patterns compared to typically developing children, intensifying over early childhood, with implications for developmental and adaptive functioning.
Andreas Zembrzycki, Adam M Stocker ... Dennis DM O'Leary
Primary and higher order visual area dimensions in the neocortex are determined by the same genetic mechanisms during development which in turn also control the proportionate scaling between them.
A retinotopic proto-organization present at birth provides the infrastructure for the subsequent development of visual cortex that commences at the onset of visual experience.