A high-throughput functional validation system for large numbers of candidate disease genes enables in vivo functional testing of specific gene variants.

A computer model built on insights gained from comprehensive experimental analysis reveals mechanisms of blood stem cell regulation.

A systematic high-throughput neurohistological and computational pipeline for marmoset which establishes a foundational setup in brain mapping and circuit tracing to support current and emerging research in primate studies.

A spike sorting toolbox to quickly and reliably access the activity of thousands of neurons recorded with dense extracellular probes.

Inter-individual human brain alignment that uses macro-anatomical priors in addition to cortical curvature improves micro-anatomical correspondence between auditory areas.

Apical and basal dendrites contribute differently to single-neuron orientation selectivity, highlighting the impact of feedforward and feedback signal interactions.

Genetic variants that modulate transcriptomic response to doxorubicin in human iPSC-derived cardiomyocytes are predictive of cardiac damage and in vivo sensitivity to anthracycline cardiotoxicity.

Cell encapsulation-based transcriptional profiling using myogenic progenitors reveals that long-range factors in the aged systemic environment induce a wide range of signaling pathways in a niche-independent manner.

An integrated framework for in vivo base edting allows to scalably validate candidate genes and DNA variants.

The in vivo transcriptomic fingerprint encoding defective decidualization comprises 120 genes associated with an imbalance hormonal signaling in the decidual endometria of women who developed severe preeclampsia.