Michael P Dalton, Mary Hongying Cheng ... Jonathan A Coleman
The structure of the vesicular monoamine transporter 2 bound to Huntington’s chorea drug tetrabenazine elucidates mechanisms of inhibition and neurotransmitter transport.
An unbiased genome-wide human forward genetic screen identifies the vacuolar ATPase complex and assembly factors as regulators of HIF stability through their actions on intracellular iron metabolism.
Kiersten A Henderson, Adam L Hughes, Daniel E Gottschling
Protons are pumped out of mother cells by a protein that accumulates over time and this leads to cellular aging, but this protein is largely absent from daughter cells, which mediates rejuvenation.
Charles Ducrot, Gregory de Carvalho ... Louis-Eric Trudeau
A combination of electrophysiological, electrochemical, and anatomical experiments sheds new light on how the complex neurotransmitter repertoire of dopaminergic neurons in the brain is regulated by proteins of the neurexin family.
Darpan Medhi, Alastair SH Goldman, Michael Lichten
Different homologous recombination pathways are dominant in different regions of meiotic chromosomes, indicating that chromosome structure influences recombination biochemistry.
Jose Ernesto Canton-Josh, Joanna Qin ... Yevgenia Kozorovitskiy
For cerebellar unipolar brush cells that regulate information flow to the vestibulo-cerebellum, dopaminergic modulation by locus coeruleus axons presents a new example of monoaminergic co-release poised to regulate the activity of the cerebellar cortex.
Sara N Mouton, David J Thaller ... Liesbeth M Veenhoff
In mitotically aging yeast cells, the cytosol acidifies, the distances between the organellar membranes decrease dramatically, but crowding on the scale of the average size protein is relatively stable.