Male and female mice respond differently to the same pheromone signals, and the representation of these sensory stimuli by neurons in the medial amygdala correlates precisely with the differences in behavior.
Jennifer M Lin, Tyler A Mitchell ... Paolo Emanuele Forni
In vivo genetic experiments show that aberrant expression of a transcription factor can compromise the functionality of neurons which is important to better understand the potential mechanisms underlying neuropathologies.
Oxytocin signaling plays a critical role in a molecularly defined neuronal population of the Medial Amygdala to modulate the behavioral and physiological responses of male mice to females on a moment-to-moment basis.
Sensory neurons in the olfactory system develop from two different regions of the ectoderm, the olfactory placode and the cranial neural crest, whereas sensory neurons within the eye and ear develop from just one region.
Michael Garratt, Ilkim Erturk ... Richard A Miller
Early-life exposure to conspecific urine and bedding extends the lifespan of female mice, indicating that social chemosensory cues can influence aging in a mammal.
Samuel Andrew Malone, Georgios E Papadakis ... Paolo Giacobini
Mouse in vivo and in vitro analysis and human genetic screening highlight the role of anti-Müllerian hormone (AMH) signaling in GnRH neuronal development and function, and identify mutations in AMH and AMHR2 in CHH patients.
A genome-organizing protein that is present only in the olfactory system of mice has been found to orchestrate changes in the relative numbers of different odor-sensing neurons on the basis of how active these neurons are.
Identification of two classes of mouse vomeronasal receptors for female pheromone cues suggests distinct gating mechanisms in pheromone-triggered reproductive behaviors.
Women with unexplained miscarriages have an altered behavioral and brain response to men's body-odor, and this may reflect a factor in their condition.