1,104 results found
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Within-host evolutionary dynamics of seasonal and pandemic human influenza A viruses in young children

    Alvin X Han, Zandra C Felix Garza ... Colin A Russell
    The longer duration of seasonal influenza virus infection in young children may provide opportunities for within-host evolution as a result of maintenance of genetic diversity through mutation-selection balance.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections

    Stefano G Giulieri, Romain Guérillot ... Benjamin P Howden
    A large-scale analysis of Staphylococcus aureus within-host evolution based on a comprehensive catalogue of bacterial genetic variation reveals an excess of genome degradation signatures in infecting strains and new genetic loci of clinically relevant adaptation.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Parallel evolution of influenza across multiple spatiotemporal scales

    Katherine S Xue, Terry Stevens-Ayers ... Jesse D Bloom
    Influenza evolution within infected hosts recapitulates many evolutionary dynamics observed at the global scale.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    A large effective population size for established within-host influenza virus infection

    Casper K Lumby, Lei Zhao ... Christopher JR Illingworth
    Once an influenza infection is established, selection acts efficiently in favouring fitter viral genotypes, its effects being limited only by the short length of a typical infection.
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    1. Evolutionary Biology

    More effective drugs lead to harder selective sweeps in the evolution of drug resistance in HIV-1

    Alison F Feder, Soo-Yon Rhee ... Pleuni S Pennings
    The transition from bad to good treatments for HIV was accompanied by a shift from soft sweeps of many drug resistance mutations spreading simultaneously to harder sweeps of one drug resistant genotype at a time.
    1. Microbiology and Infectious Disease

    Vaccination decreases the risk of influenza A virus reassortment but not genetic variation in pigs

    Chong Li, Marie R Culhane ... Montserrat Torremorell
    Vaccination has the potential to decrease swine influenza diversification by restricting influenza virus co-infections and reassortment events in pigs.
    1. Evolutionary Biology

    Symptom evolution following the emergence of maize streak virus

    Adérito L Monjane, Simon Dellicour ... Darren P Martin
    Phylogenetic analyses demonstrate an evolutionary trade-off between the amount of harm inflicted by a broad host-range virus and how effectively the virus positions itself within plants to enable onward transmission.
    1. Ecology
    2. Evolutionary Biology

    Convergence between the microcosms of Southeast Asian and North American pitcher plants

    Leonora S Bittleston, Charles J Wolock ... Anne Pringle
    Host characteristics drive the assembly of similar communities within the convergently evolved and geographically distant pitcher ecosystems of carnivorous pitcher plants.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Asynchrony between virus diversity and antibody selection limits influenza virus evolution

    Dylan H Morris, Velislava N Petrova ... Colin A Russell
    Despite the virus' error prone polymerase, influenza virus antigenic evolution is rare, even in previously immune hosts, virus replication occurs before producing new antibodies.
    1. Cell Biology
    2. Evolutionary Biology

    Chimeric origins of ochrophytes and haptophytes revealed through an ancient plastid proteome

    Richard G Dorrell, Gillian Gile ... Chris Bowler
    An in silico reconstruction of a chloroplast that existed hundreds of millions of years ago casts new insights in the evolutionary processes, endosymbioses and chimerism events that shape the origin of plastids.

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