Novel modelling strategies can integrate the dynamics of processes regulating the intestinal epithelium at multiple scales in homeostasis and following perturbations to provide unprecedented insights into the biology of the epithelium and support the development of safer novel drug candidates.
Tailoring Boolean models to 488 prostate cancer patients and 8 cell lines data allows for the experimentally validated personalisation of drug treatments.
The crystal structure of Norrie Disease Protein in complex with the extracellular cysteine-rich domain of Frizzled4 receptor and sucrose octasulfate reveals binding sites for Frizzled4, low density lipoprotein receptor related protein 5/6, and proteoglycan.
Receptors for two distinct pathways are linked to choreograph the dynamic interaction of Wnt on the stem cell membrane, which leads to the control of asymmetric cell division.
The signaling requirements to decouple proliferation of pancreatic progenitors from differentiation were elucidated and employed for the reproducible expansion, under GMP-compliant conditions, of pancreatic progenitors derived from different human pluripotent stem cell lines.
John P Russell, Xinhong Lim ... Cynthia L Andoniadou
Stem cells of the pituitary gland contribute to organ growth cell non-autonomously by promoting proliferation of committed progenitors through WNT ligand secretion.
Alexandre P Thiery, Ariane SI Standing ... Gareth J Fraser
The development of diverse tooth shapes among vertebrates, from sharks to mammals, is a highly conserved process, utilising a similar dental signalling centre for more than 400 million years.