2,090 results found
    1. Cell Biology
    2. Developmental Biology

    Cell lineage and cell cycling analyses of the 4d micromere using live imaging in the marine annelid Platynereis dumerilii

    B Duygu Özpolat, Mette Handberg-Thorsager ... Guillaume Balavoine
    Lineage tracing at single-cell resolution reveals the presence of mesoteloblasts, the embryonic origin of mesodermal growth zone cells, and diverse cell cycling patterns of these lineages in the 'Polychaete' annelid Platynereis.
    1. Computational and Systems Biology

    Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models

    Morteza Chalabi Hajkarim, Ella Karjalainen ... Kyoung-Jae Won
    compaRe can be used to optimize cytometric high-parameter immunophenotypic characterization of heterogeneous cell populations.
    1. Chromosomes and Gene Expression

    Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus

    Constance Kleijwegt, Florent Bressac ... Armelle Corpet
    Dual function of promyelocytic leukemia nuclear bodies (PML NBs) acting as buffering centers modulating the nuclear distribution of HIRA, and as chromosomal hubs regulating interferon-stimulated genes (ISGs) transcription, and thus HIRA-mediated H3.3 deposition/recycling at ISGs upon inflammatory response.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region

    Courtney M Schroeder, Jonathan ML Ostrem ... Ronald D Vale
    The dynein light intermediate chain is a member of the G protein superfamily and links the motor to several intracellular cargo adaptors.
    1. Plant Biology

    Multiple pairs of allelic MLA immune receptor-powdery mildew AVRA effectors argue for a direct recognition mechanism

    Isabel ML Saur, Saskia Bauer ... Paul Schulze-Lefert
    Allelic MLA immune receptors have an exceptional propensity to directly detect sequence-unrelated pathogen effectors and this feature might have facilitated functional diversification of the receptor in the host population.
    1. Evolutionary Biology

    Host-pathogen coevolution increases genetic variation in susceptibility to infection

    Elizabeth ML Duxbury, Jonathan P Day ... Ben Longdon
    A history of coevolution increases genetic variation in the susceptibility of Drosophila to viruses, largely by introducing major-effect resistance polymorphisms into populations.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells

    Nuria Vilaplana-Lopera, Vincent Cuminetti ... Paloma Garcia
    Interplay between AML and stromal cells can initiate a mechanism involving gap junctions where ROS is transferred from cancer cells to stromal cells which then produce acetate which can in return be absorbed/utilised by the cancer cells.
    1. Physics of Living Systems
    2. Cell Biology

    Physical basis of large microtubule aster growth

    Keisuke Ishihara, Kirill S Korolev, Timothy J Mitchison
    Autocatalytic growth of a microtubule polymer network allows extremely large egg cells to self-organize and divide rapidly.
    1. Microbiology and Infectious Disease

    Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies

    Myriam Scherer, Clarissa Read ... Thomas Stamminger
    Characterization of PML subnuclear structures during human cytomegalovirus infection demonstrates that prolonged interferon and DNA damage signaling can induce giant PML nuclear bodies which sequentially entrap both nucleic acids and viral proteins as a cytoprotective mechanism.
    1. Ecology
    2. Computational and Systems Biology

    Community-level cohesion without cooperation

    Mikhail Tikhonov
    A model of purely competitive ecological dynamics is shown to be equivalent to adaptive evolution of a single individual, suggesting a new way to formalize the "superorganism" metaphor.

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