101 results found
    1. Computational and Systems Biology
    2. Ecology

    Expanding xylose metabolism in yeast for plant cell wall conversion to biofuels

    Xin Li, Vivian Yaci Yu ... Jamie HD Cate
    Parallel pathways of xylose metabolism identified in fungi that grow on plants can be used in yeast to promote hemicellulose conversion to biofuels.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ligand modulation of sidechain dynamics in a wild-type human GPCR

    Lindsay D Clark, Igor Dikiy ... Daniel M Rosenbaum
    Generation of a highly deuterated 13C-methyl labeled wild-type GPCR sample is used to facilitate characterization of the molecular environments and fast ps-ns dynamics of sidechains when the receptor is bound to ligands of different efficacy.
    1. Cell Biology

    Selective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytes

    Konrad Lang, Julian Milosavljevic ... Tobias Hermle
    To maintain the filtration barrier, slit diaphragms are cleansed by rapid cycles of raft-mediated endocytosis, while dynamin-dependent endocytosis prevents lateral diffusion of slit diaphragm protein.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Lysosomal membrane glycoproteins bind cholesterol and contribute to lysosomal cholesterol export

    Jian Li, Suzanne R Pfeffer
    LAMP proteins, the major glycoproteins of the lysosome membrane, bind cholesterol directly and specifically, and interact with NPC1 and NPC2 proteins as part of the lysosomal cholesterol export process.
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    1. Biochemistry and Chemical Biology

    Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin

    Rima S Chakrabarti, Sally A Ingham ... Helen H Hobbs
    Accessible cholesterol levels in human red blood cells were found to be stable within individuals but vary >10-fold among individuals and this variability may contribute to differences in cholesterol trafficking among tissues.
    1. Cell Biology
    2. Immunology and Inflammation

    Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo

    Asif J Iqbal, Tessa J Barrett ... Edward A Fisher
    Mechanistic insights show how treatment with apoA1 is anti-inflammatory by rapidly disrupting macrophage chemotaxis and monocyte recruitment.
    1. Cell Biology

    A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection

    David B Heisler, Kristen A Johnson ... Arun Radhakrishnan
    An essential role for ACAT in conferring 25HC-mediated protection against bacterial and viral infection has been uncovered.
    1. Cell Biology

    Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade

    Laurence Abrami, Tiziano Dallavilla ... F Gisou van der Goot
    Cycles of palmitoylation-depalmitoylation by an upstream palmitoyltransferase allow precise tuning of DHHC6 activity, which in turn regulates the abundance and function of key ER proteins involved in protein folding, degradation, ER architecture and calcium homeostasis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges

    Libin Liu, Paul F Pilch
    PTRF (Cavin-1) mediates metabolism-regulated ribosomal transcription in mature adipocytes, independent of its role in caveolae formation.
    1. Microbiology and Infectious Disease

    Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress

    Suneeta Chimalapati, Marcela de Souza Santos ... Kim Orth
    Considering the course of a pathogen's evolution, there appears to be interplay between secretion systems, providing unique, synergistic mechanisms to support a successful lifestyle for possibly pathogenesis, symbiosis and/or parasitosis.

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