11 results found
    1. Microbiology and Infectious Disease

    N6-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression

    Nagaraja Tirumuru, Boxuan Simen Zhao ... Li Wu
    Human proteins that add or remove the methyladenosine modification of cellular RNA, or recognize methylated RNA significantly affect HIV-1 infection or viral protein synthesis in cells, suggesting an important role for HIV-1 RNA methylation in regulating viral replication.
    1. Genetics and Genomics
    2. Plant Biology

    The YTHDF proteins ECT2 and ECT3 bind largely overlapping target sets and influence target mRNA abundance, not alternative polyadenylation

    Laura Arribas-Hernández, Sarah Rennie ... Peter Brodersen
    The Arabidopsis N6-methyladenosine (m6A) binding proteins ECT2 and ECT3 act redundantly in the cytoplasm to regulate m6A-containing mRNAs whose abundances are reduced in ect2/ect3/ect4 knockout plants although the locations of their polyadenylation sites remain unaffected, contrary to currently held beliefs.
    1. Genetics and Genomics
    2. Plant Biology

    Principles of mRNA targeting via the Arabidopsis m6A-binding protein ECT2

    Laura Arribas-Hernández, Sarah Rennie ... Peter Brodersen
    The Arabidopsis N6-methyladenosine (m6A)-binding protein ECT2 binds to m6A in the canonical RR[m6A]CH motif, not a plant-specific motif as previously thought, and its intrinsically disordered region contributes to mRNA binding via contacts with U-rich motifs.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast

    Radhika A Varier, Theodora Sideri ... Folkert J van Werven
    N6-methyladenosine (m6A) reader Pho92 is directed by Paf1C to meiotic mRNAs in an m6A-dependent and independent manner and promotes CCR4-NOT-mediated mRNA decay of m6A modified transcripts contingent on translation.
    1. Developmental Biology
    2. Immunology and Inflammation

    A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells

    David J Turner, Alexander Saveliev ... Martin Turner
    A genetic screening approach identifies RNA binding proteins that enhance or inhibit the accumulation of CD138+ plasma cells in vitro, and chimeric mouse models demonstrate that YTHDF2 promotes the accumulation of antibody secreting cells in vivo.
    Short Report Updated
    Formats available:
    • HTML
    • PDF
    1. Microbiology and Infectious Disease

    The Tudor SND1 protein is an m6A RNA reader essential for replication of Kaposi’s sarcoma-associated herpesvirus

    Belinda Baquero-Perez, Agne Antanaviciute ... Adrian Whitehouse
    SND1 has m6A-reading ability and is essential for Kaposi's sarcoma-associated lytic replication.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Promoting axon regeneration by inhibiting RNA N6-methyladenosine demethylase ALKBH5

    Dong Wang, Tiemei Zheng ... Bin Yu
    Inhibiting RNA N6-methyladenosine demethylase ALKBH5 promoted axonal regeneration of dorsal root ganglion neurons by regulating stability of Lpin2 mRNA and enhanced the survival and axonal regeneration of retinal ganglion cells.
    1. Microbiology and Infectious Disease

    A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma

    Dayana C Farhat, Matthew W Bowler ... Christopher Swale
    The epitranscriptomic-driven mRNA polyadenylation pathway protects transcriptome integrity by restricting transcriptional read-throughs and RNA chimera formation in apicomplexan parasites and plants.

Refine your results by:

Type
Research categories