1,398 results found
    1. Developmental Biology

    Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography

    Yifu Ding, Daniel J Vanselow ... Keith C Cheng
    X-ray histotomography produces the first 3-dimensional images with the combined submicron resolution, centimeter fields-of-view, soft-tissue contrast, and potential throughput to enable quantitative, histopathological and centimeter-scale phenotyping for whole-organism phenomics.
    1. Computational and Systems Biology
    2. Developmental Biology

    A quantitative modelling approach to zebrafish pigment pattern formation

    Jennifer P Owen, Robert N Kelsh, Christian A Yates
    A mathematical modelling approach to understanding zebrafish stripe pattern formation exemplifies a biological rule-set sufficient to generate wild-type and a diverse range of mutant patterns.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly

    Hiroshi Yamaguchi, Toshiyuki Oda ... Hiroyuki Takeda
    Zebrafish genetics and cryo-electron tomography reveal distinct roles of all vertebrate PIH family proteins in axonemal dynein assembly and cilia/flagella motions, assigning specific dynein subtypes to each PIH protein.
    1. Cell Biology
    2. Developmental Biology

    Whole-organism 3D quantitative characterization of zebrafish melanin by silver deposition micro-CT

    Spencer R Katz, Maksim A Yakovlev ... Keith C Cheng
    Melanin staining for micro-CT imaging, using a novel application of ionic silver deposition, enables qualitative and quantitative 3D analysis of zebrafish pigmentation and reveals subtle phenotypes missed by light microscopy.
    1. Neuroscience

    A bidirectional network for appetite control in larval zebrafish

    Caroline Lei Wee, Erin Yue Song ... Sam Kunes
    Brain imaging and behavioral analysis reveal two opposing states of hunger, represented by anti-correlated lateral and caudal hypothalamic dynamics that are important for the homeostatic control of feeding in zebrafish.
    1. Developmental Biology
    2. Evolutionary Biology

    Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network

    Joaquín Letelier, Lorena Buono ... Juan R Martínez-Morales
    Depletion of vsx genes in zebrafish confirms a conserved role in bipolar cells specification across vertebrates, but do not interfere with the formation of the neural retina domain, which reveal an unexpected robustness of the genetic network sustaining the retina.
    1. Developmental Biology

    Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes

    Laura E Kuil, Nynke Oosterhof ... Tjakko J van Ham
    Embryonic and definitive macrophages require colony-stimulating factor 1 receptor, whereas non-hematopoietic metaphocytes that resemble macrophages do not, explaining the relative high numbers of putative macrophages in Csf1r-deficient zebrafish.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Pigment cell progenitor heterogeneity and reiteration of developmental signaling underlie melanocyte regeneration in zebrafish

    William Tyler Frantz, Sharanya Iyengar ... Craig J Ceol
    Zebrafish pigment cell progenitors are a heterogeneous class of adult tissue-resident cells which reiterate developmental signaling during melanocyte regeneration.
    1. Cancer Biology

    Defining function of wild-type and three patient-specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma

    Jiangfei Chen, Kunal Baxi ... Myron S Ignatius
    Zebrafish are an optimal model organism to study rare TP53 mutations whose functions are not readily understood.
    1. Cell Biology

    Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish

    Sharan Janjuha, Sumeet Pal Singh ... Nikolay Ninov
    During aging, the pancreatic endocrine islets undergo chronic inflammation, which is associated with a reduced capacity for self-renewal of the insulin-producing beta-cells in zebrafish.

Refine your results by:

Type
Research categories