A specific cluster of plasmatocytes responds to oxidative stress with immune activation by Jak/STAT, DDR and JNK signaling.
(A) Key transcription factors (TFs) regulating hemocytes states. Heat map of scaled TF activity at a single cell level in hemocytes states from Figure 2C. Colors in the heat map correspond to scaled expression. Numbers on top indicate the cluster identity. Labels on the left and right indicate the TFs. (B) Feature plots showing scaled expression of selected genes associated with JAK/STAT signaling (upd3, Socs36E, TotA, TotM, Fas3), JNK and DNA damage signaling (puc, Gadd45), insulin signaling (Thor, InR), TGFβ signaling (dpp, daw) and TNF signaling (egr).