Network of α-arrestins and their associated protein complexes
Network of α-arrestins and the functional protein complexes that significantly interact with them in human (A) and Drosophila (B). α-arrestins are colored yellow and prey proteins in protein complexes are colored according to the SAINTexpress scores (averaged if the protein interacts with multiple α-arrestins). The thickness of the green arrows indicates the strength of the interaction between α-arrestins and the indicated protein complexes, which was estimated with FDR of complex association scores (see “Materials and Methods”). UB, ubiquitination; HDAC, histone deacetylase; COMPASS, complex proteins associated with Set1; SMN, survivor of motor neurons; TFIIIC, transcription factor III C; RNA polII, RNA polymerase II; MCM, minichromosome maintenance protein complex; SAC, spindle assembly checkpoint; NSL, non-specific lethal; WASH, Wiskott-Aldrich syndrome protein and scar homolog; Arp2/3, actin related protein 2/3; TEF, transcription elongation factor.