.site-header{margin-top:calc(36/var(--base-font-size)*1rem);margin-bottom:calc(36/var(--base-font-size)*1rem)}@media only all and (min-width:768px){.site-header{margin-top:calc(48/var(--base-font-size)*1rem)}}@media only all and (min-width:1200px){.site-header{margin-bottom:calc(54/var(--base-font-size)*1rem)}}.site-header-container{align-items:center;display:flex;justify-content:space-between}@media only all and (min-width:1000px){.site-header-container{justify-content:unset}}.site-header__title{border:0;clip:rect(0 0 0 0);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;-webkit-user-select:none;-ms-user-select:none;user-select:none;width:1px}.site-header__logo_link{line-height:0}@media only all and (min-width:1000px){.nav-primary{margin-left:calc(20/var(--base-font-size)*1rem);border-left:var(--border);display:inline-block;height:24px}}.nav-primary__list{padding-left:calc(0/var(--base-font-size)*1rem);padding-top:calc(0/var(--base-font-size)*1rem);align-items:top;display:flex;justify-content:top;margin:0}.nav-primary__item{font-size:calc(14/var(--base-font-size)*1rem);line-height:1.7142857143;padding-left:calc(24/var(--base-font-size)*1rem);color:var(--link-decoration);display:none;font-family:var(--font-family-primary);font-weight:700;list-style-type:none}.nav-primary__item a{color:var(--link-decoration);text-decoration:none}.nav-primary__item a:hover{color:var(--color-primary)}.nav-primary__item.nav-primary__item--inactive a{pointer-events:none}@media only all and (min-width:1000px){.nav-primary__item{display:list-item}}.nav-primary__item--first{padding-left:calc(0/var(--base-font-size)*1rem);display:list-item}.nav-primary__item--first a{padding-right:calc(48/var(--base-font-size)*1rem);background:url(https://elifesciences.org/reviewed-preprints/_next/static/media/nav-primary-menu-ic.8cf9e8b8.svg) no-repeat right 0;background-size:24px;display:block;width:24px}.nav-primary__item--first a:hover{background-image:url(https://elifesciences.org/reviewed-preprints/_next/static/media/nav-primary-menu-blue-ic.f69455fc.svg);color:var(--color-primary)}@media only all and (min-width:1000px){.nav-primary__item--first{text-indent:-9999px}.nav-primary__item--first a{padding-right:calc(24/var(--base-font-size)*1rem)}}.nav-secondary{margin-top:calc(10/var(--base-font-size)*1rem);display:none}@media only all and (min-width:1000px){.nav-secondary{margin-top:calc(0/var(--base-font-size)*1rem);display:block;margin-left:auto}}.nav-secondary__list{display:flex;float:right;margin:0;padding:0}.nav-secondary__item{font-size:calc(14/var(--base-font-size)*1rem);line-height:1.7142857143;margin-top:calc(2/var(--base-font-size)*1rem);padding-left:calc(24/var(--base-font-size)*1rem);color:var(--link-decoration);font-family:var(--font-family-primary);font-weight:700;list-style-type:none}.nav-secondary__item--search{padding-right:calc(30/var(--base-font-size)*1rem);background:url(https://elifesciences.org/reviewed-preprints/_next/static/media/search.103c8dc0.svg) no-repeat right 0;background-size:21px}.nav-secondary__item--search a{color:var(--link-decoration);text-decoration:none}.nav-secondary__item--search a:hover{color:var(--color-primary)}.nav-secondary__item--alert{padding-right:calc(30/var(--base-font-size)*1rem);background:url(https://elifesciences.org/reviewed-preprints/_next/static/media/alerts.94767051.svg) no-repeat right 0;background-size:21px}.nav-secondary__item--alert a{color:var(--link-decoration);display:block;text-decoration:none}.nav-secondary__item--alert a:hover{color:var(--color-primary)}.block-button{font-size:calc(11/var(--base-font-size)*1rem);line-height:2;border-radius:3px;color:var(--color-text);font-weight:400;height:24px;text-decoration:none;text-transform:uppercase;white-space:nowrap}.block-button.block-button__variant-one{margin-top:calc(1/var(--base-font-size)*1rem);padding:calc(5/var(--base-font-size)*1rem) calc(9/var(--base-font-size)*1rem) calc(3/var(--base-font-size)*1rem) calc(9/var(--base-font-size)*1rem);background-color:var(--color-primary);color:#fff}.main-menu__section{padding-bottom:calc(15/var(--base-font-size)*1rem)}.main-menu__title{padding-bottom:calc(18/var(--base-font-size)*1rem);padding-left:calc(0/var(--base-font-size)*1rem);margin-top:calc(30/var(--base-font-size)*1rem);align-items:center;display:flex;justify-content:space-between}@media only screen and (min-width:1200px){.main-menu__title{margin-top:calc(48/var(--base-font-size)*1rem)}}.main-menu__list{padding-left:calc(0/var(--base-font-size)*1rem)}.main-menu__list_item{font-size:calc(16/var(--base-font-size)*1rem);line-height:3;padding-bottom:calc(24/var(--base-font-size)*1rem);display:block;font-family:var(--font-family-primary);line-height:0;text-align:left}@media only screen and (min-width:1000px){.main-menu__list_item.hidden-wide{display:none}}.main-menu__list_item.end-of-group{margin-bottom:calc(24/var(--base-font-size)*1rem);border-bottom:var(--border)}.main-menu__list_item:last-child{padding-bottom:calc(48/var(--base-font-size)*1rem)}.main-menu__list_link{font-size:calc(14/var(--base-font-size)*1rem);line-height:1.7142857143;color:var(--color-text);font-weight:700;text-decoration:none}.main-menu__list_link:hover{color:var(--color-primary)}.main-menu__close_control{font-size:calc(14/var(--base-font-size)*1rem);line-height:1.7142857143;background:url(https://elifesciences.org/reviewed-preprints/_next/static/media/close.b8f8aff4.svg) no-repeat 49px 5px;background-size:14px;border:none;color:var(--color-text);cursor:pointer;font-family:var(--font-family-primary);font-weight:700;padding:0;text-align:left;width:68px}.main-menu__close_control:hover{background-image:url(https://elifesciences.org/reviewed-preprints/_next/static/media/close-blue.e90fd568.svg);color:var(--color-primary)}.main-menu__container:hover{color:var(--color-primary)}.main-menu__container .site-header__title{margin-bottom:calc(30/var(--base-font-size)*1rem);float:none}.main-menu--js{display:none}.main-menu--js .main-menu__container{display:block}.main-menu--js.main-menu--shown{z-index:40;background-color:#fff;box-sizing:border-box;color:var(--color-text);display:block;float:left;height:100vh;left:-3000px;max-width:100%;overflow:auto;position:fixed;top:0;-webkit-transform:translate3d(3000px,0,0);transform:translate3d(3000px,0,0);width:100%}@media only screen and (min-width:1000px){.main-menu--js.main-menu--shown{width:320px}}.main-menu--js .main_menu__quit{display:none}.overlay{z-index:30;background-color:rgba(0,0,0,.8);height:100vh;position:fixed;top:0;width:100vw}.to-top-link{display:none}.wrapper{box-sizing:content-box;margin:auto;max-width:calc(1200px/var(--base-font-size)*1rem);padding-left:var(--site-spacing);padding-right:var(--site-spacing)}@media only screen and (min-width:480px){.wrapper{padding-left:var(--site-spacing-large);padding-right:var(--site-spacing-large)}}.site-header__skip_to_content{display:block;left:20px;position:absolute;top:20px;white-space:nowrap}.site-header__skip_to_content__link{border:0;clip:rect(0 0 0 0);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;-webkit-user-select:none;-ms-user-select:none;user-select:none;width:1px;padding:calc(15/var(--base-font-size)*1rem) calc(36/var(--base-font-size)*1rem) calc(14/var(--base-font-size)*1rem);z-index:50}.site-header__skip_to_content__link:focus{clip:auto;height:auto;margin:0;overflow:auto;position:static;width:auto;position:absolute}.site-footer{border-top:1px solid var(--divider);padding-top:calc(48/var(--base-font-size)*1rem);padding-bottom:calc(16/var(--base-font-size)*1rem)}.footer-navigation{padding-bottom:calc(48/var(--base-font-size)*1rem)}.footer-navigation__list{list-style:none;margin:0;padding:0;text-align:center}.footer-navigation__list_item{font-size:calc(11/var(--base-font-size)*1rem);line-height:2.1818181818;color:var(--color-text);font-family:var(--font-family-primary);letter-spacing:.5px;text-transform:uppercase}.footer-navigation__list_link{color:var(--color-text);text-decoration:none}.footer-navigation__list_link:hover{color:var(--color-primary)}.site-smallprint__copyright_link{color:var(--color-text);text-decoration:none}.site-smallprint__copyright_link:hover{color:var(--color-primary)}@media only all and (min-width:768px){.footer-navigation__list{-webkit-column-count:2;column-count:2;-webkit-column-gap:.5rem;column-gap:.5rem;text-align:left}.footer-navigation__list_item{-webkit-column-break-inside:avoid;break-inside:avoid-column}}.site-smallprint{font-family:var(--font-family-secondary);padding:0 6%;text-align:center}.site-smallprint,.site-smallprint small{font-size:calc(11/var(--base-font-size)*1rem);line-height:2.1818181818}.site-smallprint small{display:block}.carbon-neutral-wrapper{text-align:center}.carbon-neutral-wrapper .carbon-neutral-link{margin:calc(0/var(--base-font-size)*1rem) calc(0/var(--base-font-size)*1rem) calc(47/var(--base-font-size)*1rem);align-items:center;display:inline-flex;flex-flow:row wrap;justify-content:center;max-width:247px}@media only all and (min-width:768px){.carbon-neutral-wrapper{text-align:left}.site-footer__container{padding:calc(0/var(--base-font-size)*1rem) calc(6%/var(--base-font-size)*1rem);display:table;display:flex;flex-wrap:wrap;margin:auto;max-width:1200px}.site-footer__container .grid-cell:first-child{padding-bottom:calc(12/var(--base-font-size)*1rem);flex:1 1 50%;float:left;width:50%}.site-footer__container .grid-cell:nth-child(2){padding-bottom:calc(12/var(--base-font-size)*1rem);flex:1 1 50%;float:right;width:50%}.site-footer__container .grid-cell:nth-child(3){clear:both;flex:1 1 100%;width:100%}.site-smallprint{padding:0;text-align:left}.site-smallprint__copyright{text-align:center}.small{padding-bottom:calc(24/var(--base-font-size)*1rem)}.address{padding-bottom:calc(84/var(--base-font-size)*1rem);font-style:normal}.site-footer__container{padding:0 6%}.footer-navigation{padding-bottom:calc(72/var(--base-font-size)*1rem)}}.social-links{padding:calc(0/var(--base-font-size)*1rem) calc(0/var(--base-font-size)*1rem) calc(19/var(--base-font-size)*1rem) calc(0/var(--base-font-size)*1rem);text-align:center}.social-links__list{margin:0;padding:1px 0 0}.social-links__list_item{padding:calc(0/var(--base-font-size)*1rem) calc(5/var(--base-font-size)*1rem);display:inline-block;margin:0}.social-links__list_link svg path{fill:var(--color-text)}.social-links__list_link:hover svg path{fill:var(--color-primary)}.github-link-wrapper{text-align:center}.github-link-wrapper .github-link{margin:calc(0/var(--base-font-size)*1rem) calc(0/var(--base-font-size)*1rem) calc(60/var(--base-font-size)*1rem);align-items:center;color:var(--color-text);display:inline-flex;flex-flow:row wrap;justify-content:center;min-height:24px;text-decoration:none;text-transform:uppercase;width:auto}.github-link-wrapper .github-link svg path{fill:var(--color-text)}.github-link-wrapper .github-link:hover svg path{fill:var(--color-primary)}.github-link-wrapper .github-link:hover{color:var(--color-primary)}.github-link-wrapper .github-link .github-link--text{font-size:calc(11/var(--base-font-size)*1rem);line-height:2.1818181818;margin:calc(2/var(--base-font-size)*1rem) calc(0/var(--base-font-size)*1rem) calc(0/var(--base-font-size)*1rem) calc(7/var(--base-font-size)*1rem);color:var(--color-text);font-family:var(--font-family-primary);letter-spacing:.5px;text-transform:uppercase}@media only all and (min-width:768px){.social-links{text-align:left}.github-link-wrapper{text-align:left;text-align:initial}.github-link-wrapper .github-link{margin:calc(0/var(--base-font-size)*1rem) calc(0/var(--base-font-size)*1rem) calc(72/var(--base-font-size)*1rem);justify-content:start}.social-links__list_item{padding:0;padding-right:calc(24/var(--base-font-size)*1rem)}}.investor-logos{list-style:none;margin:0;padding-left:0}.investor-logos__item{padding:calc(24/var(--base-font-size)*1rem);border-top:1px solid var(--divider)}.investor-logos__container{max-width:calc(185/var(--base-font-size)*1rem);height:calc(72/var(--base-font-size)*1rem);margin:auto;text-align:center}@supports(display:flex){.investor-logos__container{align-items:center;display:flex;justify-content:center}}.investor-logos__img{display:block;height:100%;object-fit:contain;width:100%}@media only all and (min-width:480px){.investor-logos{border-top:1px solid var(--divider);display:table;table-layout:fixed;width:100%}.investor-logos__item{border:0;border-right:1px solid var(--divider);display:table-cell;vertical-align:top}.investor-logos__item:last-child{border-right:0}}.email-cta{padding-top:calc(48/var(--base-font-size)*1rem);padding-bottom:calc(72/var(--base-font-size)*1rem);border-top:1px solid var(--divider);text-align:center}.email-cta__container{box-sizing:content-box;margin:0 auto;max-width:27.5rem;padding:0 6%}.email-cta__header_text{padding-top:calc(24/var(--base-font-size)*1rem);padding-bottom:calc(24/var(--base-font-size)*1rem);font-size:calc(20/var(--base-font-size)*1rem);line-height:1.2;color:var(--color-text);font-family:var(--font-family-primary);margin:0}.email-cta__privacy{display:block;font-size:calc(12/var(--base-font-size)*1rem);line-height:2;margin-bottom:calc(4/var(--base-font-size)*1rem);margin-top:calc(12/var(--base-font-size)*1rem)}.email-cta__privacy_link{color:var(--color-text-secondary);font-family:var(--font-family-primary);text-decoration:none}.email-cta__privacy_link:hover{color:var(--color-primary);text-decoration:underline}.button{padding:calc(8/var(--base-font-size)*1rem) calc(18/var(--base-font-size)*1rem);font-size:calc(14/var(--base-font-size)*1rem);line-height:1.7142857143;color:var(--color-text);font-family:var(--font-family-primary);background-color:var(--color-primary);border:0;border-radius:4px;color:#fff;cursor:pointer;display:inline-block;font-weight:700;letter-spacing:.2px;text-decoration:none}.button:hover{background-color:var(--color-primary-dark)}.button--action{background-color:var(--color-button);color:var(--color-text);font-weight:600;text-transform:none}.button--action:hover{background-color:#d7d9de}.button--cite-download,.button--clipboard{padding:calc(12/var(--base-font-size)*1rem) calc(18/var(--base-font-size)*1rem) calc(14/var(--base-font-size)*1rem) calc(18/var(--base-font-size)*1rem);border:none;margin:0 auto;max-height:48px;width:100%}.button--cite-download{background-color:var(--color-button);color:var(--color-text)}.button--cite-download:hover{background-color:#d7d9de}.button--icon-download{padding-left:calc(41/var(--base-font-size)*1rem);background:url(https://elifesciences.org/reviewed-preprints/_next/static/media/download.dc5558b7.svg) var(--color-button) no-repeat 11px 15px;vertical-align:middle}.button--icon-download.button--action{padding-right:calc(20/var(--base-font-size)*1rem);background-position-y:8px}.button--icon-share{padding-left:calc(41/var(--base-font-size)*1rem);background:url(https://elifesciences.org/reviewed-preprints/_next/static/media/share.96abf7c5.svg) var(--color-button) no-repeat 11px 15px;vertical-align:middle}.button--icon-share.button--action{padding-right:calc(20/var(--base-font-size)*1rem);background-position-y:8px}.button--icon-citation{padding-left:calc(41/var(--base-font-size)*1rem);background:url(https://elifesciences.org/reviewed-preprints/_next/static/media/cite.8510d9bd.svg) var(--color-button) no-repeat 11px 15px;vertical-align:middle}.button--icon-citation.button--action{padding-right:calc(20/var(--base-font-size)*1rem);background-position-y:8px}.button--icon-follow{padding-left:calc(41/var(--base-font-size)*1rem);background:url(https://elifesciences.org/reviewed-preprints/_next/static/media/follow.dddfa855.svg) var(--color-button) no-repeat 11px 15px;vertical-align:middle}.button--icon-follow.button--action{padding-right:calc(20/var(--base-font-size)*1rem);background-position-y:8px}:root{--color-primary:#087acc;--color-primary-dark:#0769b0;--color-text:#212121;--color-text-secondary:#757575;--color-button:#edeff4;--color-background:#f7f7f7;--divider:#e0e0e0;--link-decoration:#212121;--border:1px solid var(--divider);--font-family-primary:noto sans,arial,helvetica,sans-serif;--font-family-secondary:noto serif,serif;--grid-gutter:24px;--site-spacing:24px;--site-spacing-large:48px;--base-font-size:16}:after,:before{box-sizing:border-box}.visuallyhidden{border:0;clip:rect(0 0 0 0);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;-webkit-user-select:none;-ms-user-select:none;user-select:none;width:1px}.grid-container{max-width:1200px}@media only all and (min-width:480px){@supports(display:grid){.grid-container{display:grid;grid-column-gap:var(--grid-gutter);grid-template-columns:repeat(12,1fr)}}}@media only all and (min-width:480px){.grid-header{grid-column:1/13;grid-row:1}.primary-section-header{grid-column:1/13;grid-row:2}}@media only all and (min-width:768px){.primary-section-header{grid-column:2/12}}@media only all and (min-width:1000px){.primary-section-header{grid-column:1/9}}@media only all and (min-width:1200px){.primary-section-header{padding-right:calc(36/var(--base-font-size)*1rem);grid-column:1/10}}@media only all and (min-width:480px){.primary-section{grid-column:1/13;grid-row:4}}@media only all and (min-width:768px){.primary-section{grid-column:2/12}}@media only all and (min-width:1000px){.primary-section{grid-column:1/9;grid-row:3}}@media only all and (min-width:1200px){.primary-section{padding-right:calc(36/var(--base-font-size)*1rem);grid-column:1/10}}@media only all and (min-width:480px){.side-section{grid-column:1/13;grid-row:3}}@media only all and (min-width:768px){.side-section{align-items:start;display:flex;flex-direction:row;grid-column:2/12}}@media only all and (min-width:1000px){.side-section{z-index:30;align-items:end;align-self:flex-start;flex-direction:column;grid-column:9/13;grid-row:2/4;justify-content:space-between;margin-top:62px;position:-webkit-sticky;position:sticky;top:125px}}@media only all and (min-width:1200px){.side-section{z-index:30;grid-column:10/13}}.article-page{padding-left:var(--site-spacing);padding-right:var(--site-spacing);padding-bottom:calc(96/var(--base-font-size)*1rem);margin:0 auto}@media only screen and (min-width:480px){.article-page{padding-left:calc(var(--site-spacing)*2);padding-right:calc(var(--site-spacing)*2)}}