4,526 results found
    1. Neuroscience

    Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery

    Rebekah Elizabeth Mahoney et al
    By regulating protein translation within the neuron, insulin signaling can control neuronal activity by altering the release of neurotransmitter molecules.
    Research Article Updated
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    1. Biochemistry
    2. Cell Biology

    Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

    Lars Plate et al
    Small molecule proteostasis regulators that activate the unfolded protein response transcription factor ATF6 reduce the secretion of amyloid disease-associated proteins.
    Research Article
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    1. Cell Biology
    2. Plant Biology

    Arabidopsis heterotrimeric G proteins regulate immunity by directly coupling to the FLS2 receptor

    Xiangxiu Liang et al
    Heterotrimeric G proteins are coupled to and regulate plant receptor signaling, which allows optimum immune activation and enhances the production of reactive oxygen species.
    Research Article Updated
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    1. Neuroscience

    CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins

    Lizhen Chen et al
    Genetics and genomics approaches reveal a conserved post-transcriptional regulatory mechanism that promotes adult axon regeneration from worm to mammals.
    Research Article Updated
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    1. Neuroscience

    Hippocampal pattern completion is linked to gamma power increases and alpha power decreases during recollection

    Bernhard P Staresina et al
    Direct recordings from the human hippocampus reveal the neural mechanisms that orchestrate recollection of past experiences.
    Research Article
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    1. Microbiology and Infectious Disease

    The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

    Stephen Patterson et al
    Biological and pharmacokinetic studies indicate that the anti-tubercular drug, delamanid, could be repurposed for the treatment of visceral leishmaniasis.
    Research Article
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    1. Biochemistry
    2. Cell Biology

    Correction: Nanobodies: site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation

    Tino Pleiner et al
    Correction
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    1. Biochemistry
    2. Biophysics and Structural Biology

    Crystal structure of an HIV assembly and maturation switch

    Jonathan M Wagner et al
    Folding and unfolding of a 6-helix bundle controls HIV assembly and maturation.
    Research Article Updated
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    1. Computational and Systems Biology
    2. Genes and Chromosomes

    Single-cell analysis of transcription kinetics across the cell cycle

    Samuel O Skinner et al
    By properly accounting for gene copy number and cell-cycle effects, single cell snapshots of nascent and mature mRNA can be used to unveil the stochastic kinetics of gene activity.
    Short Report Updated
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    1. Neuroscience

    Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans

    Calogero Maria Oddo et al
    Delivering specific patterns of electrical activity to the median nerve of the arm triggers reliable sensations of texture, suggesting that it may ultimately be possible to restore complex tactile information to users of prosthetic limbs.
    Research Article
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