1,686 results found
  1. Fabry Disease: Ion channels and neuropathic pain

    Madeleine C Klein, Anne Louise Oaklander
    Pain behaviors in a Fabry mouse model are associated with the accumulation of a fat molecule that disrupts sodium ion channels in small fiber neurons.
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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: SARS-CoV-2 (COVID-19) by the numbers

    Yinon M Bar-On et al.
    Key numbers about the biology of the SARS-CoV-2 virus and the infection of a single human host by the virus have been compiled from the peer-reviewed literature.
    1. Medicine

    Research: Adequate statistical power in clinical trials is associated with the combination of a male first author and a female last author

    Willem M Otte et al.
    An analysis of 31,873 clinical trials shows that adequate statistical power was most often present in trials with a male first author and a female last author.
    1. Computational and Systems Biology
    2. Neuroscience

    Meta-Research: Dataset decay and the problem of sequential analyses on open datasets

    William Hedley Thompson et al.
    Open data provides an opportunity to perform new analyses on preexisting data, but trade-offs are required to limit an increase in false positives.
    1. Biochemistry and Chemical Biology

    Enzyme Mechanisms: Wedging open a catalytic site

    Annie Beuve
    The activation mechanism of the nitric oxide receptor has been revealed by cryo-electron microscopy.
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    1. Computational and Systems Biology
    2. Genetics and Genomics

    Cutting Edge: Lessons from Fraxinus, a crowd-sourced citizen science game in genomics

    Ghanasyam Rallapalli et al.
    A citizen science game reveals play interest patterns that could inform crowdsourcing experiment design.
    1. Developmental Biology
    2. Neuroscience

    Microscopy: Imaging far and wide

    Raghav K Chhetri, Philipp J Keller
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    1. Developmental Biology
    2. Neuroscience

    Extrinsic activin signaling cooperates with an intrinsic temporal program to increase mushroom body neuronal diversity

    Anthony M Rossi, Claude Desplan
    The activin ligand myoglianin acts as a temporal extrinsic cue to regulate the intrinsic temporal factor Imp in mushroom body neuroblasts, increasing neuronal diversity by specifying the α’β’ fate.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes

    Yohei Ohashi et al.
    The lipid kinase VPS34 complexes I and II are both activated by unsaturation of substrate and non-substrate lipids, curvature, electrostatics and polyphosphoinositides, which play roles in localisation and cellular function.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Deep evolutionary analysis reveals the design principles of fold A glycosyltransferases

    Rahil Taujale et al.
    Deep mining of GT-A fold sequences provides an evolutionary framework for investigating complex relationships connecting GT-A fold sequence, structure, function and regulation.

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