125 results found
    1. Structural Biology and Molecular Biophysics

    Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of ‘quasi-ordered’ states

    Amanda F Clouser et al.
    Multiple iso-energetic-specific interactions involving the intrinsically-disordered region of sHSP HSPB1 define a quasi-ordered state, providing insights into inherited disease-associated mutations within the region that are thought to be disordered.
    1. Structural Biology and Molecular Biophysics

    Structural basis of phosphatidylcholine recognition by the C2–domain of cytosolic phospholipase A2α

    Yoshinori Hirano et al.
    The C2-domain of cytoplasmic phospholipase A2α is structurally designed to target PC-rich membrane regions to increase the enzymatic efficiency of the catalytic domain, which prefers PCs with polyunsaturated acyl chains.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure-based inhibitors of amyloid beta core suggest a common interface with tau

    Sarah L Griner et al.
    Aβ inhibitors effectively block its aggregation, while also reducing seeding of tau aggregation from Aβ, tau, and AD derived fibrils, suggesting the two share a structurally related disease relevant interface.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status

    Dongming Li et al.
    The METHYL-CpG-BINDING DOMAIN 7 (MBD7) complex promotes the activation (rather than repression) of transgenes that undergo DNA methylation and it does so without significantly altering their methylation status, placing this complex downstream of DNA methylation.
    1. Structural Biology and Molecular Biophysics

    Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes

    Lejla Zubcevic et al.
    Ligand-induced two-fold symmetric arrangement in TRPV2 is observed in the native-like nanodisc-reconstituted condition using cryo-electron microscopy.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution

    Michael Luke Carlson et al.
    A simple, yet elegant method for robust self-assembly of diverse membrane proteins into soluble peptide nanoparticles for their structural and functional analysis in detergent-free solutions.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases

    Niels Bradshaw et al.
    Structures of active and inactive conformations of a PP2C family phosphatase reveal a conserved switch that controls enzymatic activity and point to an unexpected relationship between phosphatases and proteasomal proteases.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

    Jone Paesmans et al.
    Structural and biochemical data suggest a mechanism for the Synaptojanin1-catalysed reaction and the role of mutations in the onset of associated neurological diseases.
    1. Structural Biology and Molecular Biophysics

    Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme

    Zhening Zhang et al.
    Integrative structural analyses of human insulin degradingenzyme (IDE) reveal how IDE selectively degrades peptides that form toxicaggregates, which guides IDE-based therapeutic innovations to treat diabetesand Alzheimer's disease.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Recreating the synthesis of starch granules in yeast

    Barbara Pfister et al.
    Yeast cells can be engineered to study starch, the semi-crystalline storage carbohydrate from plants that is central to human nutrition.

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