484 results found
    1. Microbiology and Infectious Disease

    Factors essential for L,D-transpeptidase-mediated peptidoglycan cross-linking and β-lactam resistance in Escherichia coli

    Jean-Emmanuel Hugonnet et al.
    Production of the L,D-transpeptidase YcbB and elevated synthesis of the (p)ppGpp alarmone reveals a new mode of peptidoglycan polymerization that bypasses the D,D-transpeptidase activity of PBPs and leads to broad-spectrum β-lactam resistance in Escherichia coli.
    1. Microbiology and Infectious Disease

    Efficacy of β-lactam/β-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of Mycobacterium tuberculosis

    Saurabh Mishra et al.
    Intrinsic tolerance of Mycobacterium tuberculosis toward the world's most successful antibacterials, β-lactams, is dependent on cytoplasmic redox potential and an intracellular redox-sensor WhiB4.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Comprehensive exploration of the translocation, stability and substrate recognition requirements in VIM-2 lactamase

    John Z Chen et al.
    Comprehensive mutational characterisation of VIM-2 metallo-beta-lactamase deciphered the residues responsible for key functional behavior, including translocation, stability, substrate recognition and catalysis.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen Pseudomonas aeruginosa

    Camilo Barbosa et al.
    Evolutionary trade-offs enhance efficacy of antibiotic therapy by constraining bacterial adaptation in dependence of drug order and trade-off effect size.
    1. Microbiology and Infectious Disease

    Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions

    Elizabeth A Mueller et al.
    Environmental specialization of bacterial cell wall synthases influences intrinsic resistance to cell wall active antibiotics.
    1. Cell Biology
    2. Neuroscience

    Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration

    Guiping Wang et al.
    Neurotrophin deprivation leads to rapid caspase-independent disassembly of the actin-spectrin-based membrane skeleton and spectrin-dependent retrograde signaling in axon degeneration.
    1. Structural Biology and Molecular Biophysics
    2. Evolutionary Biology

    An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases

    Jeffrey I Boucher et al.
    The convergent evolution of unusually strict substrate specificity in apicomplexan LDHs arose by classic neofunctionalization of a duplicated MDH gene via few mutations of large effect.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Delayed antibiotic exposure induces population collapse in enterococcal communities with drug-resistant subpopulations

    Kelsey M Hallinen et al.
    Collapse of bacterial communities containing antibiotic-resistant and susceptible cells can be driven by increased population size or delayed drug exposure.
    1. Cell Biology

    A novel checkpoint pathway controls actomyosin ring constriction trigger in fission yeast

    Tomás Edreira et al.
    In fission yeast cell wall stress triggers a cytokinesis blockage specifically in the onset of actomyosin ring constriction.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis

    Haik Mkhikian et al.
    Structurally dissimilar N-glycans can be functionally equivalent, and are produced via a self-correcting feature of the Golgi.

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