150 results found
    1. Biochemistry and Chemical Biology

    Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice

    Fanbiao Meng et al.
    SIRT1 deacetylates SIRT6 at K33 to facilitate DNA double-strand breaks-recognition, subsequent expansion and local chromatin remodeling.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration

    Konstantinos Sousounis et al.
    Experimental manipulation of a core DNA damage response factor and cell-cycle checkpoint regulators reveals a key role for these processes in the progenitor cells that fuel limb regeneration.
    1. Cell Biology

    SIRT6 is a DNA double-strand break sensor

    Lior Onn et al.
    Hundreds of proteins are involved in the DNA damage response but only three sensors for DSB were known but now SIRT6 is identified as a fourth DSB sensor.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11

    Takahiko Akematsu et al.
    The first genetic compelling evidence for post-meiotic DNA double-strand breaks and its relation to chromatin remodeling in haploid pronuclei is shown.
    1. Cancer Biology

    Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis

    Ian M Cartwright et al.
    Myc expression is shown to cause sublethal activation of Caspase-3 and downstream endonuclease G, which causes DNA double strand breaks and oncogenic transformation in human cells.
    1. Microbiology and Infectious Disease

    Mycobacterium tuberculosis exploits host ATM kinase for survival advantage through SecA2 secretome

    Savita Lochab et al.
    Mycobacterium tuberculosis (Mtb), effectors secreted through SecA2 pathway cause double strand breaks (DSBs) in the host DNA, which in turn activates ATM kinase to gain survival advantages, through Akt.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Distinct roles for S. cerevisiae H2A copies in recombination and repeat stability, with a role for H2A.1 threonine 126

    Nealia CM House et al.
    Despite differing by only one amino acid in the C-terminal tail, copy 1 of yeast histone 2A has a repair-specific role not shared by copy 2.
    1. Cell Biology

    A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1

    Natalia Felipe-Medina et al.
    Genetic and biochemical analysis reveal a variant in HSF2BP causing POI and C19ORF57/BRME1 as an interactor and stabilizer of HSF2BP by forming a complex with BRCA2, RAD51, RPA and PALB2.
    1. Developmental Biology
    2. Genetics and Genomics

    Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice

    Mohamed Mahgoub et al.
    The meiotic recombination landscape in vertebrates was re-engineered via the co-evolution of a dual histone H3K4/H3K36 methylation 'writer' PRDM9 and its 'reader' ZCWPW1 that facilitates efficient double strand break repair.
    1. Cancer Biology

    Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth

    Romi Gupta et al.
    The protein IFI6 regulates DNA replication via the transcription factor E2F2, which is necessary for transformation and growth of melanomas induced by the NRASQ61K mutant oncogene product.

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