6,462 results found
    1. Developmental Biology
    2. Evolutionary Biology

    CRISPR knockouts reveal an endogenous role for ancient neuropeptides in regulating developmental timing in a sea anemone

    Nagayasu Nakanishi, Mark Q Martindale
    Analysis of the endogenous function of deeply conserved neuropeptides in sea anemones sheds light on a primitive role of nervous systems in modulating developmental timing.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Non-invasive measurement of mRNA decay reveals translation initiation as the major determinant of mRNA stability

    Leon Y Chan et al.
    Non-invasive mRNA stability measurements reveal that transcript lifetime is governed by a competition with translation initiation on a transcriptome-wide level.
    1. Immunology and Inflammation

    Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation

    Gaojian Lian et al.
    Metabolic reprogramming in suppressing oxidative stress during TH17 cell differentiation.
  1. eLife latest: We welcome two new Senior Editors

    Two Reviewing Editors now join eLife’s leadership team.
    1. Neuroscience

    Human VMPFC encodes early signatures of confidence in perceptual decisions

    Sabina Gherman, Marios Philiastides
    1. Neuroscience

    Poor coherence in older people's speech is explained by impaired semantic and executive processes

    Paul Hoffman et al.
    Remaining focused on the topic at hand when speaking depends on effective selection of task-relevant semantic knowledge, and declines in this ability account for increases in off-topic speech in older people.
    1. Neuroscience

    Building a functional connectome of the Drosophila central complex

    Romain Franconville et al.
    The central complex, a highly conserved insect brain region important for navigation, is characterized by a high degree of recurrence and a sparseness of output pathways.
    1. Neuroscience

    Adaptation after vastus lateralis denervation in rats demonstrates neural regulation of joint stresses and strains

    Cristiano Alessandro et al.
    The adaptation strategy used by the nervous system following muscle paralysis restores task performance while minimizing the stresses and strains within a joint.
  2. Meta-research: Researchers study implicit bias in peer review

    eLife editors and staff are collaborating to better understand, and begin to address, bias in the outcomes of peer review.

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