A mechanistic dissection of how autophagy kinase Atg1 is activated in fission yeast reveals surprising differences from the known Atg1 activation mechanisms previously defined in budding yeast.
Microscopic and biochemical analysis show that the stress-activated MAP kinase pathway targets the formin For3 to modulate actomyosin ring integrity in response to environmental cues.
Neuronal neurofascin takes a surprisingly circuitous route in the neuronal plasma membrane to the axon initial segment where it stabilises ion channel complexes responsible for initiating action potentials.
A systematic set of experiments reveals how properdin specifically directs AP activation independently of primary C3 deposition additionally as an alternative convertase stabilizer, thus revising immune machinery of complement activation.
Duplication of Leishmania chromosomes combines S-phase DNA replication initiated at a single internal region with subtelomeric DNA replication detectable outside S-phase, potentially explaining genome plasticity in this important parasite.
The structure of the Legionella pneumophilaType IV secretion system provides the detailed molecular model of this complex molecular machine required for pathogenesis.
Stoichiometric interactions between microtubules and cortical force-generators set spindle size, position and dynamics, and its scaling with cell size in nematode species.
