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    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death

    Laurelle Jackson et al.
    Under conditions where the force of HIV infection per cell is high, partial attenuation of infection with inhibitors can increase the number of live infected cells and may paradoxically be beneficial for viral spread.
    1. Neuroscience

    Role of the visual experience-dependent nascent proteome in neuronal plasticity

    Han-Hsuan Liu et al.
    A screen of visual-experience induced changes in newly-synthesized proteins in Xenopus optic tectum identifies unexpected candidate plasticity proteins.
    1. Neuroscience

    Species-specific modulation of food-search behavior by respiration and chemosensation in Drosophila larvae

    Daeyeon Kim et al.
    In naturalistic conditions, larvae of the Drosophila group exhibit species-specific strategies to search for food resources through a primitive form of risk-taking behavior that is controlled by a tradeoff between exploitation and odor-driven exploration.
    1. Neuroscience

    Occurrence of long-term depression in the cerebellar flocculus during adaptation of optokinetic response

    Takuma Inoshita, Tomoo Hirano
    Motor training decreased the unit synaptic response and suppressed induction of long-term depression at parallel fiber to Purkinje cell synapses in the cerebellum, supporting involvement of long-term depression in motor learning.
  1. Scientific Publishing: How early-career researchers are shaping eLife

    Mark Patterson, Randy Schekman
    Journals can benefit from listening to graduate students, postdocs and newly-independent group leaders.
    Editorial
    Available as:
    • HTML
    • PDF
    1. Neuroscience

    Orphan receptor GPR158 controls stress-induced depression

    Laurie P Sutton et al.
    The orphan receptor GPR158 is highly regulated by stress exposure and acts on key neuronal signaling pathways in the prefrontal cortex to control depressive-like behaviors.
    1. Neuroscience

    Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs

    Sébastien Houy et al.
    Doc2B functions in two distinct vesicle priming steps; membrane localization occludes upstream Ca2+-dependent priming, whereas Ca2+-binding and interaction with synaptotagmin-1, SNAREs, and Munc13-2 are involved in downstream priming, which makes vesicles readily releasable.
    1. Chromosomes and Gene Expression

    The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis

    Sarah N Deffit et al.
    Identification of tissue-specific RNA editing using a robust, publicly-available platform (SAILOR) reveals noncoding A-to-I editing events required for proper gene expression and neurological function, significantly advancing the understanding of how ADARs function in neural cells.