Multi-omics reveals that Alkb homolog 7 (ALKBH7), α mitochondrial alpha-ketoglutarate dioxygenase of unclear function, regulates glyoxal metabolism, which may explain its role in necrosis and heart attack.
The aged human auditory cortex shows preserved tonotopy, but temporal modulations are represented with a markedly broader tuning, highlighting decreased temporal selectivity as a hallmark of the aging auditory cortex.
Mitochondrial-targeted SS-31 peptide ameliorates mitochondrial dysfunction and rescues pre-existing cardiac dysfunction in old mice, supporting the translational potential of mitochondrial protective interventions to treat age-related diseases.
A comprehensive, data-driven and interpretable nonlinear computational modeling framework based on deep neural networks uncovers different nonlinear transformations of speech signal in the human auditory cortex.
By combining ultra-high-field imaging with physiological and saliva measures it is established that interactions between locus coeruleus, hippocampus and amygdala vary along emotional memory stages, putatively reflecting distinct cognitive states.