5 results found
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Engineering induction of singular neural rosette emergence within hPSC-derived tissues

    Gavin T Knight, Brady F Lundin ... Randolph Scott Ashton
    A bioengineering approach identifies tissue morphology as an effective variable for controlling the inception of neural organoid morphogenesis via induction of a biomimetic, singular neural rosette tissue cytoarchitecture.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Discovery of a metabolic alternative to the classical mevalonate pathway

    Nikki Dellas, Suzanne T Thomas ... Joseph P Noel
    A combination of phylogenetic and biochemical analyses suggest that some unexpected variations in the synthesis of isoprenoids may be widespread across all three domains of life.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement

    Aleksandra Zielińska, Abigail Savietto ... Dirk-Jan Scheffers
    Correct cell wall synthesis in bacteria depends on flotillin-mediated membrane fluidity.
    1. Structural Biology and Molecular Biophysics

    Novel sterol binding domains in bacteria

    Liting Zhai, Amber C Bonds ... Laura MK Dassama
    A combination of bioinformatics, protein biochemistry, and X-ray crystal structures reveals new bacterial proteins that are capable of binding to sterols.
    1. Structural Biology and Molecular Biophysics
    2. Evolutionary Biology

    Methylation at the C-2 position of hopanoids increases rigidity in native bacterial membranes

    Chia-Hung Wu, Maja Bialecka-Fornal, Dianne K Newman
    Methylation specifically enhances the ability of hopanoids to rigidify membranes under physiologically relevant conditions, which impacts the current interpretation of the 2-methylhopane fossil record.

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