Discovery of potent covalent TEAD palmitoylation inhibitors that represents important tools to investigate the Hippo pathway.

Circadian control of neuronal excitability in the master circadian clock of a diurnal mammal as revealed by whole-cell recording and mathematical modeling.

Two distinct types of inhibitory neurons increase the brain's sensitivity to unexpected acoustic signals by amplifying selective suppression of cortical responses to frequent, but not rare sounds.

The calcium-dependent signaling pathway during ABA-dependent stomatal closure requires the calcium-independent pathway, and calcium signaling specificity is mediated by PP2C protein phosphatases.

The signaling ligand (p)ppGpp regulates the enzyme HPRT across species by binding to a novel class of conserved motif, yet its specificity is allosterically altered through evolution of enzyme oligomerization.

The interplay between the opposing responses mediated by different chemoreceptors enables bacteria to swim towards a preferred temperature.

Chemical modifications near the tRNA anticodon and specific mRNA–tRNA pairs combine to control the ribosomal three-nucleotide mRNA reading frame, essential for the sequential addition of amino acids into polypeptide chains.

Crystal structures of Nanos bound to Pumilio and target RNAs demonstrate how Nanos forms a molecular clamp to alter Pumilio RNA regulation and specificity in embryonic development and germline maintenance.

Multiple dynamic protein interactions converge to regulate the catalytic activity of the B cell kinase, BTK.

Native state dynamics of mouse prion protein were measured, and these motions were shown to be having a role in initiation of aggregation.