9,027 results found
    1. Developmental Biology
    2. Cancer Biology

    MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells

    Kent Riemondy et al.
    Inhibition of microRNA-203 by oncogenic HRas mutations promotes skin cancer initiation.
    1. Structural Biology and Molecular Biophysics

    2.8 Å resolution reconstruction of the Thermoplasma acidophilum 20S proteasome using cryo-electron microscopy

    Melody G Campbell et al.
    Water molecules and amino-acid side chain rotamers have been resolved in the cryoEM structure of T20S proteasome at 2.8 angstroms.
    1. Epidemiology and Global Health

    Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up

    Xia Li et al.
    Biological ages have the potential to provide aging-related information beyond chronological age and can be predictive of mortality independently of both chronological age and different types of biological ages.
    1. Developmental Biology

    MicroRNA-mediated control of developmental lymphangiogenesis

    Hyun Min Jung et al.
    Lymphatic-enriched microRNA miR-204 is required for lymphatic development through its effects on the key lymphatic transcription factor NFATC1.
    1. Developmental Biology
    2. Evolutionary Biology

    Origin of the mechanism of phenotypic plasticity in satyrid butterfly eyespots

    Shivam Bhardwaj et al.
    A gradual, step-wise, physiological/molecular response of eyespot size to temperature is a likely adaptation to seasonal variation experienced in the habitat of Bicyclusanynana butterflies.
    1. Developmental Biology

    Co-expression of Foxa.a, Foxd and Fgf9/16/20 defines a transient mesendoderm regulatory state in ascidian embryos

    Clare Hudson et al.
    Ascidian mesendoderm is a transient regulatory state upstream of mesoderm and endoderm gene regulatory networks and required for the initiation of both.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent

    Hideo Imamura et al.
    Genome sequencing reveals the evolution and epidemiology of Leishmania donovani in the Indian subcontinent, where epidemics have caused up to 30,000 deaths per year.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Molecular dynamics-based refinement and validation for sub-5 Å cryo-electron microscopy maps

    Abhishek Singharoy et al.
    New hybrid structure determination methods leveraging the inherent biophysical properties of a macromolecule through molecular dynamics simulations provide accurate and cost-efficient ways of achieving atomic structures from high resolution cryo-electron density maps.
    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon et al.
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
    1. Genetics and Genomics

    Point of View: Bioengineering horizon scan 2020

    Luke Kemp et al.
    20 emerging issues in bioengineering that will have profound impacts on society have been identified.

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