Jaebin Kim, Edwin Bustamante ... Scott H Soderling
Presynaptic Rac1 inhibition in the hippocampus impairs spatial working memory, potentially by modulating the synaptic cytoskeleton and kinase-mediated phosphorylation of key synaptic vesicle proteins.
In vitro model of germline specification in marmosets established by directed differentiation of induced pluripotent stem cells, which transcriptionally resemble pre-migratory primordial germ cells in vivo.
Abril Angélica Escamilla-Ayala, Ragna Sannerud ... Wim Annaert
Super-resolution microscopy sets a new strategy to comprehend the membrane organization of γ-secretase at single complex resolution identifying nanodomain associations and its diffusion in situ in the living membrane.
Mikhail Kudryashev, Marco Stenta ... Henning Stahlberg
The basal body of the type-III secretion system of Yersinia enterocolitica within bacterial membranes shows elasticity and is longer than related isolated systems.
Felipe Trajtenberg, Juan A Imelio ... Alejandro Buschiazzo
The molecular mechanism of switching between phosphotransferase- and phosphatase-competent states in histidine-kinases has been uncovered, through direct crystallographic observation of bona fide complexes between a histidine-kinase and its response regulator from Bacillus subtilise.
Opportunistic bacteria modulate their lifestyle from coexistence to pathogenicity by perceiving the physiological state of their algal host through sensing of algal secreted metabolites.
Tania Moreno-Mármol, Mario Ledesma-Terrón ... Paola Bovolenta
Retinal pigment epithelium flattening is an efficient solution adopted by the fast-developing zebrafish to enable folding of the eye primordia, which contrasts with the proliferation-based mechanism used by amniotes.