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The Saccharomyces cerevisiae spliceosome component Fyv6 contributes to precursor messenger RNA splicing by promoting use of branch site distal 3' splice sites and interacting with key factors involved in exon ligation.

Rigorous biochemical and structural analyses reveal the precise topology of cohesin's association with DNA and suggest a mechanism for how DNA is transported inside the ring.

Unique integrate stress response sensors differentially trigger pro-survival versus pro-apoptotic responses in cells confronted with Hsp70 inhibitor-associated proteotoxic challenges.

Generation of a home-and-rescue gene drive targeting an essential gene reveals confinable population modification.

A high-throughput method to profile tyrosine kinases and phosphotyrosine recognition domains reveals new rules for sequence specificity and maps the effects of mutations on the recognition of tyrosine phosphorylation sites.

Membrane homeostasis in bacteria relies on the controlled degradation of endogenous phospholipids by intracellular phospholipases A, however their structures and catalytic mechanism are still poorly understood.

Extensive analysis shows that the RNA-binding protein SAFB binds to Drosha in hippocampal stem cells and controls oligodendrocyte fate commitment through post-transcriptional regulation of NFIB expression.