hRPA permits the BLM helicase to bidirectionally unwind DNA from a nick which could potentially facilitate its function switching in DNA repair and promote end resection in homologous recombination.
Gergana Shipkovenska, Alexander Durango ... Danesh Moazed
Genetic and biochemical studies show that a conserved ribosome biogenesis complex also localizes to heterochromatin, where it triggers RNA degradation and promotes the spreading and epigenetic inheritance of histone methylation.
Salma Sohrabi-Jahromi, Katharina B Hofmann ... Patrick Cramer
Mapping of 30 general RNA degradation factors onto the yeast transcriptome provides the global distribution of factors for RNA turnover and surveillance in a eukaryotic cell.
Julia Takuno Hespanhol, Daniel Enrique Sanchez-Limache ... Ethel Bayer-Santos
Salmonella antibacterial effectors act on Y-shaped DNA substrates resembling replication forks or transcription bubbles and lead to DNA double-strand breaks.
Archaea can contain permuted versions of the universal signal recognition particle RNA, which require a moonlighting activity of the tRNA splicing machinery to generate functional circular RNAs.
Degradosome-associated nucleases PNPase and RNase J2 are required for type III CRISPR immunity against diverse nucleic acid invaders originating from plasmid and phage.
Yoshitaka Kawasoe, Toshiki Tsurimoto ... Tatsuro S Takahashi
Biochemical analysis in Xenopus egg extracts reveals that the MutSα mismatch sensor retains the DNA-bound replication clamp to maintain a post-replicative temporal window permissive to strand-specific repair of mismatches.
The structures of full-length Las1-Grc3 complexes provide crucial insights into the activation mechanism of HEPN nuclease and the pathway of pre-rRNA processing in ribosome biosynthesis.
Justin D Lormand, Soo-Kyoung Kim ... Holger Sondermann
Dinucleases, specialized enzymes that catalyze the final step in RNA degradation, have evolved independently and repeatedly to fulfill essential roles in cell growth.
