In sensory ciliated neurons, FoxN4 Forkhead (FKH) transcription factors directly coregulate transcription of ciliome genes together with RFX transcription factors, a similar regulatory logic to what is found for motile-cilium cell types, suggesting an ancestral origin for this partnership.

Anti-targets are proteins that cause problems when inhibited along with an intended target and our novel chemical strategy affords unprecedented selectivity in the context of FLT3 vs. KIT inhibition for treatment of a devastating blood cancer.

Specific inhibition of cyclin-dependent kinase-like 5 (CDKL5), a kinase linked to a severe neurodevelopmental disorder, demonstrates an important role in the regulation of excitatory hippocampal synapses and synaptic plasticity that was not previously appreciated in rodent knock-out models.

A coordinated tissue movement during C. elegans central nervous system internalization reveals a novel role for HMR-1/cadherin in maintaining cohesion, and extends the concept of neurulation beyond vertebrates.

Real-time ³³P imaging combined with specific complementation of inorganic phosphate transport in the root cap reveals this tissue’s contribution to phosphate uptake.

Advanced glycation end-products (compounds which make the food appetizing and aromatic) intricately modulate organism’s homeostatic and hedonistic signaling pathways thereby inducing preferential consumption of excess nutrients offering preliminary insights into overconsumption of modern-day processed food.