6,493 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    ARL3 activation requires the co-GEF BART and effector-mediated turnover

    Yasmin ElMaghloob et al.
    BART is a co-GEF for ARL3 and maintains the active ARL3-GTP until it is recycled by ARL3 effectors.
    1. Neuroscience

    Cadherin preserves cohesion across involuting tissues during C. elegans neurulation

    Kristopher M Barnes et al.
    A coordinated tissue movement during C. elegans central nervous system internalization reveals a novel role for HMR-1/cadherin in maintaining cohesion, and extends the concept of neurulation beyond vertebrates.
    1. Cell Biology
    2. Immunology and Inflammation

    Identification of a super-functional Tfh-like subpopulation in murine lupus by pattern perception

    Stefanie Gryzik et al.
    A novel binning approach provides evidence for super-functional T cells with high activation potential and which exhibit Tfh-like functionalities and can help B cells.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Diverse viral proteases activate the NLRP1 inflammasome

    Brian V Tsu et al.
    Proteases from diverse viruses, the first described pathogen-encoded activators of human NLRP1, cleave NLRP1 at a sequence that mimics the viral polyprotein, resulting in inflammasome activation and pro-inflammatory cytokine release.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A combination of transcription factors mediates inducible interchromosomal contacts

    Seungsoo Kim et al.
    A pooled mutational scanning approach for 3D chromosome conformation reveals how multiple transcription factors can jointly specify condition-specific genome conformations.
    1. Cell Biology
    2. Immunology and Inflammation

    A two-hybrid antibody micropattern assay reveals specific in cis interactions of MHC I heavy chains at the cell surface

    Cindy Dirscherl et al.
    A generally applicable two-hybrid assay demonstrates that MHC class I heavy chains devoid of beta-2 microglobulin associate within and across allotypes, with implications for endocytosis and autoimmunity.
    1. Evolutionary Biology

    The birth of a bacterial tRNA gene by large-scale, tandem duplication events

    Gökçe B Ayan et al.
    A bacterial tRNA gene set rapidly evolves, compensating the loss of one tRNA type by large duplication events that increase the gene copy number of a second, different tRNA type.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Metagenomic chromosome conformation capture (meta3C) unveils the diversity of chromosome organization in microorganisms

    Martial Marbouty et al.
    A technique called meta3C provides an elegant and integrated approach to metagenomic analysis by allowing the de novo assembly, scaffolding and 3D characterization of unknown genomes from a complex mix of species
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres

    Krishnendu Guin et al.
    Proximity and homology guided inter-chromosomal translocations drive karyotype evolution.
    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon et al.
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.

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