5,102 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction

    Mohsen Afshar Bakooshli et al.
    Human skeletal muscle progenitors and motor neurons self-organize in three-dimensional co-culture to form functional neuromuscular junctions that developmentally mature from the embryonic to the adult state.
    1. Cancer Biology

    Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531

    CheukMan C Au et al.
    3D culture of breast cancer in biologically relevant ECM potentiates the growth-inhibitory effects of unacylated ghrelin and AZP-531, and clinical response may be predictable based on a MAPK gene signature.
    1. Neuroscience
    2. Physics of Living Systems

    Elements of a stochastic 3D prediction engine in larval zebrafish prey capture

    Andrew D Bolton et al.
    Zebrafish implement a stochastic recursive algorithm during prey capture that reflects an implicit physical model of the world.
    1. Neuroscience

    Rapid whole brain imaging of neural activity in freely behaving larval zebrafish (Danio rerio)

    Lin Cong et al.
    The integration of a novel high spatiotemporal resolution volume imaging technique and a fast 3D tracking system allows capturing whole brain neural activities in a freely behaving larval zebrafish.
    1. Stem Cells and Regenerative Medicine

    A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids

    Henrik Renner et al.
    Automated liquid handling, whole mount staining, and clearing allow unbiased 3D quantitation of cell markers in human neural organoids with diameters of up to 1 mm at the single-cell level.
    1. Cell Biology
    2. Developmental Biology

    CytoCensus, mapping cell identity and division in tissues and organs using machine learning

    Martin Hailstone et al.
    Easy-to-use image analysis software enables single cell quantitation of cell types and division rates in complex 3D tissues including living Drosophila brains, mouse embryos and Zebrafish organoids.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Screening identifies small molecules that enhance the maturation of human pluripotent stem cell-derived myotubes

    Sridhar Selvaraj et al.
    Treatment of human pluripotent stem cell-derived myotubes with a cocktail of small molecules induces their maturation, as shown by gene expression, biochemical and functional assays.
    1. Cell Biology
    2. Ecology

    Quantitative 3D-imaging for cell biology and ecology of environmental microbial eukaryotes

    Sebastien Colin et al.
    Three-dimensional fluorescence imaging of microbial eukaryotes in environmental samples allows accurate automated taxonomic profiling and quantitative data about ultrastructures and interactions of organisms.
    1. Cancer Biology
    2. Cell Biology

    Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling

    Benjamin L Ricca et al.
    In a 3D culture model of breast epithelium, application of a short-timescale compression to single malignant cells promotes the long-timescale development of polarized, growth-arrested structures.
    1. Cancer Biology

    Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer

    Patricia L Theard et al.
    Combined EGFR and SOS1 inhibition synergize to inhibit NSCLC spheroid growth.

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