4,029 results found
    1. Cell Biology
    2. Physics of Living Systems

    Golgi compartments enable controlled biomolecular assembly using promiscuous enzymes

    Anjali Jaiman, Mukund Thattai
    By partitioning promiscuous enzymes across multiple Golgi compartments, eukaryotic cells can tightly control the synthesis of complex sugar oligomers.
    1. Neuroscience

    Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region-specific manner

    Adam J Granger et al.
    Most ChAT-expressing interneurons are a subset VIP+ interneurons that differentially release GABA and acetylcholine onto different post-synaptic targets, while a separate population of non-VIP ChAT+ neurons release acetylcholine in mPFC.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Dynamic metastable long-living droplets formed by sticker-spacer proteins

    Srivastav Ranganathan, Eugene I Shakhnovich
    Multi-scale simulations reveal a potential, ATP-independent mechanism resulting in the formation of the long-living multi-droplet state by multi-valent, spacer-sticker proteins.
  1. Research Culture: A survey-based analysis of the academic job market

    Jason D Fernandes et al.
    A survey of over 300 applicants for faculty positions reveals that there are many paths to securing a job offer.
    1. Immunology and Inflammation
    2. Physics of Living Systems

    Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers

    Marco Molari et al.
    Detailed and inferred model reproduces B-cell affinity distributions measured in mice immunized according to various protocols and explains non-monotonous effects of antigen dosage on maturation.
    1. Neuroscience

    Sleep is bi-directionally modified by amyloid beta oligomers

    Güliz Gürel Özcan et al.
    Amyloid beta, the major component of plaques in Alzheimer's disease, acutely and reversibly signals to modulate sleep as a function of oligomeric length, independently of neuronal loss.
    1. Neuroscience

    Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states

    Kevin A Bolding et al.
    Intracortical circuits in mouse olfactory cortex stabilize odor-evoked activity patterns when upstream inputs, from olfactory bulb, become degraded under anesthesia.
    1. Cell Biology
    2. Immunology and Inflammation

    CD56 regulates human NK cell cytotoxicity through Pyk2

    Justin T Gunesch et al.
    CD56/NCAM, the prototypical marker of human natural killer cells, promotes lytic function towards susceptible target cells by signaling through protein tyrosine kinase 2 (Pyk2).
    1. Genetics and Genomics

    A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21

    Yasuhiro Kazuki et al.
    TcMAC21 is an appropriate “next gen” mouse model for DS research, and provides a proof of concept of using artificial chromosomes to generate non-mosaic humanized animal models of chromosome disorders.
    1. Developmental Biology
    2. Immunology and Inflammation

    Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung at single cell resolution

    Racquel Domingo-Gonzalez et al.
    Single cell transcriptomics reveal a complex orchestration of lung immune cells during the transition from fetal to air-breathing life to fill context-specific functions in tissue remodeling, angiogenesis, and immunity.

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